PURPOSE Immunodeficient mice serve as critical hosts for transplantation of xenogeneic cells for in vivo analysis of various biological processes. Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment. Taking advantage of the increased metastatic potential of Rho...

In this study, we demonstrate a role for extracentromeric sequences in chromosome inheritance. Genetic analyses indicate that transmission of the Drosophila minichromosome Dp1187 is sensitive to the dosage of nod+, a kinesin-like gene required for the meiotic transmission of achiasmate chromosomes. Minichromosome deletions displayed increased loss rates in females heterozygous for a loss-of-fun...

Studien undersöker genomförbarheten av ett nytt judoinspirerat träningsprogram för äldre personer, Judo4Balance. Vi utvärderade inför en fullskalig studie genom att följa studieprocess, resurshantering och vetenskapliga aspekter. Ytterligare utfallsmått var fysisk funktion, tilltro till egen förmåga utföra aktiviteter utan falla samt falltekniker. Interventionen bedömdes vara genomförbar, med v...

Swarm robotics provides ways of solving problems using groups of autonomous robots that display emergent intelligent behaviour. Control mechanisms for these robots can be designed by using mechanisms from evolutionary robotics. In order to ensure that the controllers are adaptive and capable of learning new behaviour controllers are artificially evolved using techniques inspired by natural evol...

We investigate the structure of the two permutation classes defined by the sets of forbidden patterns {1234, 2341} and {1243, 2314}. By considering how the Hasse graphs of permutations in these classes can be built from a sequence of rooted source graphs, we determine their algebraic generating functions. Our approach is similar to that of “adding a slice”, used previously to enumerate various ...

Neonatal islet-specific expression of IL-10 in nonobese diabetic (NOD) mice accelerates the onset of diabetes, whereas systemic treatment of young NOD mice with IL-10 prevents diabetes. The mechanism for acceleration of diabetes in IL-10-NOD mice is not known. Here we show, by adoptive transfers, that prediabetic or diabetic NOD splenocytes upon encountering IL-10 in the pancreatic islets readi...

BACKGROUND Transplant vasculopathy (TV) is a major cause for late graft loss after cardiac transplantation. Endothelial damage and T cell infiltration play a pivotal role in the development of TV. Because N-octanoyl dopamine (NOD) inhibits vascular inflammation and suppresses T cell activation in vitro, we here tested the hypothesis that NOD treatment ameliorates TV. METHODS Aortic grafts wer...

Rabbit is one of the intangible cultural heritages in Beijing, but with popularity modern smart products, it gradually fading from public’s view. In order to better protect and help rabbit master solve problem dying out, this paper will analyze its connotation, artistic characteristics other perspectives, propose new inheritance protection strategies, including: application technology create “R...

Dendritic cells (DCs) contribute to islet inflammation and its progression to diabetes in NOD mouse model and human. DCs play a crucial role in the presentation of autoantigen and activation of diabetogenic T cells, and IRF4 and IRF8 are crucial genes involved in the development of DCs. We have therefore investigated the expression of these genes in splenic DCs during diabetes progression in NO...

NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance to transplantation tolerance induction. These two phenotypes are genetically separable. Costimulation blockade fails to prolong skin allograft survival in (NOD x C57BL/6)F1 mice and in NOD-related strains made diabetes-resistant by congenic introduction of protective major histocompatibility complex (MHC) or...