Several media report highlight on that the pharmaceutical companies require ultra-low temperatures -80°C to transport and store its COVID-19 vaccines. This research presents thermodynamic analysis cascade refrigeration system (CRS) with several refrigerant pairs which are R32/R170, R123/R170, R134a/R170, R404A/R170, R407c/R170, R410/R170, hydrocarbon (HC) pair Propane/Ethane, namely R290/R170. ...

Majid, Dewan S. A., Akira Nishiyama, Keith E. Jackson, and Alexander Castillo. Inhibition of nitric oxide synthase enhances superoxide activity in canine kidney. Am J Physiol Regul Integr Comp Physiol 287: R27–R32, 2004. First published March 25, 2004; 10.1152/ajpregu.00073.2004.—To evaluate the role of a potential interaction between superoxide anion (O2 ) and nitric oxide (NO) in regulating k...

Schizophrenia is a complex and severe mental disorder that affects about 1% of the population, clinically characterized by positive, negative, and disorganized symptoms. It is widely accepted that a combination of genetic and environmental factors lead to the onset of schizophrenia. The past two decades have witnessed the increasingly important role of cognitive deficits in schizophrenia, such ...

A series of coordination polymers containing Cu(II) and [Au(CN)(2)](-) units has been prepared. Most of their structures incorporate attractive gold-gold interactions, thus illustrating that such "aurophilic" interactions can be powerful tools for increasing structural dimensionality in supramolecular systems. [Cu(tren)Au(CN)(2)][Au(CN)(2)] (1, tren = tris(2-ethylamino)amine) forms a cation/ani...

The HIV-1 nucleocapsid protein (NC) is a small basic protein containing two zinc fingers (ZF) separated by a short linker. It is involved in several steps of the replication cycle and acts as a nucleic acid chaperone protein in facilitating nucleic acid strand transfers occurring during reverse transcription. Recent analysis of three-dimensional structures of NC-nucleic acids complexes establis...

The existence of N-formylated sugars in the O-antigens of Gram-negative bacteria has been known since the middle 1980s, but only recently have the biosynthetic pathways for their production been reported. In these pathways, glucose-1-phosphate is first activated by attachment to a dTMP moiety. This step is followed by a dehydration reaction and an amination. The last step in these pathways is c...

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor, playing key roles in maintenance of adipose tissue and in regulation of glucose and lipid homeostasis. This receptor is the target of thiazolidinediones, a class of antidiabetic drugs, which improve insulin sensitization and regulate glycemi...

We study the Generalized Second Price auctions—a standard method for allocating online search advertising—experimentally, considering both the static environment assumed by the prevailing theory and a dynamic game capturing the salient aspects of real-world search advertising auctions. Subjects of our experiment bid consistently with the leading equilibrium notions, but exhibit significant over...