Seventy five patients with severely bleeding peptic ulcer were included in a controlled comparative trial to assess the efficacy and safety of endoscopic injection therapy in preventing rebleeding from peptic ulcers that presented at endoscopy with a protruding vessel. Twenty five patients were treated with injection of epinephrine followed by polidocanol, 25 were treated with injection ofabsol...

In 1945 I was looking for a job, after having spent a short post-war convalescence as a junior assistant in the Medical Unit at St. Thomas's Hospital, when I had the good fortune to be introduced to Dr Avery Jones. He had just then had the idea that clues to the causes of gastric and duodenal ulcers might be obtained if differences could be found in the frequency with which they occurred in men...

OSTEOPOROSIS IS A MAJOR cause of disability and excess mortality in older women. Estrogen therapy has been used for treatment and prevention of osteoporosis; however, many older women are reluctant to use it because of adverse effects. Recent data from the Women’s Health Initiative demonstrated that postmenopausal women who took hormone therapy for approximately 7 years had decreased hip fractu...

 A. Carr, DSc FMedSci , Nuffield Professor of Orthopaedic Surgery  C. Cooper, MSc, Senior Trial Manager  J. Rees, MD, Professor of Orthopaedic Surgery and Musculoskeletal Science, NDORMS  D. J. Beard, DPhil, Professor of Musculoskeletal Sciences; CoDirector, Royal College of Surgeons Surgical Trials Unit (SITU-Oxford) University of Oxford, Botnar Research Centre, Windmill Road, Headington, ...

BACKGROUND AND AIM: This prospective study was aimed to compare efficacy and safety of combined surgery and sequential surgeries in patients with primary glaucoma and visually significant senile cataract. MATERIALS AND METHODS: 50 consecutive patients having coexisting visually significant senile cataract with primary glaucoma were included in study. Patients underwent detailed history, ocular ...

AIM To evaluate the effectiveness of quetiapine and haloperidol in patients of delirium referred to psychiatry consultation liaison services. METHODS The study followed a single blind randomised controlled trial design. Thirty-two patients in the haloperidol group and 31 patients in the quetiapine group were assessed at the baseline and 6 consecutive days. Flexible dosing regimen (haloperidol...

Idelalisib is a first-in-class, oral, selective phosphatidylinositol 3-kinase δ inhibitor that offers a chemotherapy-free option for patients with relapsed or refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). Clinical trials in iNHL have evaluated idelalisib as monotherapy and as combination therapy with rituximab, bendamustine, and rituximab + bendamustine. When administered to heavily pr...

OBJECTIVES The purpose of this study was to evaluate the role of heart rate reduction with beta-blockers on the risk of cardiovascular events in patients with hypertension. BACKGROUND Resting heart rate has been shown to be a risk factor for cardiovascular morbidity and mortality in the general population and in patients with heart disease such as hypertension, myocardial infarction, and hear...

To examine how measuring adherence at 3 weeks by self-report and pill counts compares to measurements 7 in a pre-randomization run-in period. Study within trial of an international parallel group randomized controlled (RCT) that spironolactone placebo. Adults receiving dialysis enter 8-week active period with spironolactone. Adherence was assessed both subgroup participants weeks. 332 entered t...

INTRODUCTION Primary biliary cirrhosis (PBC) is an autoimmune liver disease with approximately 50% of patients experiencing fatigue. This can be a particularly debilitating symptom, affecting quality of life and resulting in social isolation. Fatigue is highlighted by patients as a priority for research and patient support groups were involved in designing this trial. This is the first randomis...