Human leukemic T cells carrying a t(10;14)(q24;q11) chromosome translocation were fused with mouse leukemic T cells, and the hybrids were examined for genetic markers of human chromosomes 10 and 14. Hybrids containing the human 10q+ chromosome had the human genes for terminal deoxynucleotidyltransferase that has been mapped at 10q23-q25 and for C alpha [the constant region of TCRA (the alpha-ch...

Alveolar soft part sarcoma (ASPS), a rare soft tissue sarcoma, is characterized by a chromosomal translocation der(17)t(X;17)(p11;q25) resulting in the production of 2 fusion proteins encoded by regions of the genes for alveolar soft part locus (ASPL) and the transcription factor E3 (TFE3). In this study, polyclonal antibodies were generated to 25 mer peptides encompassing the junctional region...

Philadelphia (Ph) chromosome (9;22)(q34;q11) is well established in more than 90% of chronic myeloid leukemia (CML) patients, and the remaining 5-8% of CML patients show variant and complex translocations, with the involvement of third, fourth, or fifth chromosome other than 9;22. However, in very rare cases, the fourth chromosome is involved. Here, we found a novel case of four-way Ph+ chromos...

We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of </=40 years. These families included a total of 126 affected sibpairs and 4 other affected relative pairs. Nonparametric linkage analysis revealed seven regions showing nomina...

Fusion genes are frequently observed in hematologic malignancies and soft tissue sarcomas, and are usually associated with chromosome abnormalities. Many of these fusion genes create in-frame fusion transcripts that result in the production of fusion proteins, and some of which aid tumorigenesis. These fusion proteins are often associated with disease phenotype and clinical outcome, and act as ...

BACKGROUND Of the overall 9.5 million deaths annually in India, nearly 100,000 are due to organ failure. To save and extend lives, organ donation and organ transplantation have become the only hope. Health care professionals (HCPs) are a key element in facilitating cadaveric organ donation process. OBJECTIVE To assess and compare the knowledge, attitude, and practice regarding organ donation ...

Flood, erosion, and sedimentation have become classic problems in the river. The two main parameters that significantly affect phenomenon of flood are flow sediment. Flood sediment transport cause aggradation degradation river bed, bring bad influence to construction environment. Therefore, it becomes important conduct manipulation control channel profile selected area Special Economic Area (KE...

Summary Understanding patterns of dispersal behaviour threatened species is important in conservation biology and population ecology, especially fragmented landscapes. Dupont’s Lark Chersophilus duponti a passerine whose European has declined by around 40% the last decade. To study natal breeding species, we used long-term mark-recapture dataset (2011–2019) analysed records 32 males (39 movemen...

abstract water pricing is a policy instrument for improving water efficiency, reducing water demand, management of the irrigation systems and recovering costs. the underlying principle of water pricing is that it should reflect the opportunity cost of water. in this study, parametric mathematical programming approache were used to estimate the willingness of farmers to pay for groundwater under...