Various substituted Dispiro [pyrrolo-piperazino-oxindole] have been synthesized by utilizing a simple and efficient two-step synthetic protocol Grubbs metathesis in dichloromethane at 40°C. The structures relative stereochemistry of the cycloadduct were confirmed single-crystal X-ray diffraction, 1H 13C NMR spectroscopy, mass spectrometry.
 
 Keywords: Hexahydro-diazecane-dione, Metat...

A convenient, simple and green process for the synthesis of 2,4,5-triaryl-1H-imidazole and 1,2,4,5-tetraaryl-1H-imidazole derivatives using snail shell, which is abundant in Morocco, as a catalyst in ethanol at 40 °C has been developed. Additionally, short reaction times, excellent yields, simple procedure and relative non-toxicity of the catalyst are other noteworthy advantages and make this m...

A convenient, simple and green process for the synthesis of 2,4,5-triaryl-1H-imidazole and 1,2,4,5-tetraaryl-1H-imidazole derivatives using snail shell, which is abundant in Morocco, as a catalyst in ethanol at 40 °C has been developed. Additionally, short reaction times, excellent yields, simple procedure and relative non-toxicity of the catalyst are other noteworthy advantages and make this m...

We determine the nonlinear mechanical behavior of a prototypical zeolitic imidazolate framework (ZIF-8) along two modes of mechanical failure in response to tensile and shear forces using first-principles simulations. Our generalized stacking fault energy surface reveals an intrinsic stacking fault of surprisingly low energy comparable to that in copper, though the energy barrier associated wit...

We propose and experimentally realize a new kind of bound states in the continuum (BICs) in a class of systems constructed by coupling multiple identical one-dimensional chains, each with inversion symmetry. In such systems, a specific separation of the Hilbert space into a topological and a nontopological subspace exists. Bulk-boundary correspondence in the topological subspace guarantees the ...

To assess the effect of androgens on tyrosinase activity in B16/C3 melanoma cell cultures, proliferating cultures were treated with testosterone (50 nM) or one of several other androgenic analogues and metabolites. None of these compounds influenced basal enzyme activity. Imidazole (10 mM), however, is a potent inducer of tyrosinase in this cell line. Testosterone blocked induction of tyrosinas...

The asymmetric unit of the title compound, {[Co(3)Yb(2)(C(5)H(2)N(2)O(4))(6)(H(2)O)(4)]·2H(2)O}(n), contains one Yb(III) ion, two Co(II) ions (one situated on an inversion centre), three imidazole-4,5-dicarboxyl-ate ligands, two coordinated water mol-ecules and one uncoordinated water mol-ecule. The Yb(III) ion is seven-coordinated, in a monocapped trigonal prismatic coordination geometry, by s...

We present a high yield synthesis of 1-ethyl-3-methyl-imidazole-2-chalcogenones from readily available imidazolium-2-carboxylate zwitterions NHC−CO2 and elemental chalcogens. In sharp contrast to previous syntheses for corresponding thiones selones imidazolium salts bases our reactions proceed fast with full instead low conversion selectivity, decarboxylation is the driving force. Furthermore, ...

8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(beta-methallyl)imidazole by a tandem hydroformylation-cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole derivatives.