Certain substituted salicylaldehydes are known to have highly potent antimicrobial activity against bacteria and fungi, but the mechanism underlying this remarkable activity is not known, and almost nothing has been reported on the effects of further modification of the structures, such as the formation of hydrazone-type derivatives. We report now a study on the antimicrobial properties of the ...

1 J.B and R.B.; School of Chemical Sciences, North Maharashtra University, Jalgaon – 425001. 7 2 R.D.; Department of Biochemistry, Maharshi Dayanand University, Rohtak –124 001. 8 3 G.J.; School of Medicine, Department of clinical & translational sciences, Creighton University, Omaha, NE, 9 68178, USA. 10 * Correspondence: [email protected]; Tel.: +1-408-359-0192 (G.J); bendrers@rediffm...

Acute secretory diarrhea induced by infection with enterotoxigenic strains of Escherichia coli involves binding of stable toxin (STa) to its receptor on the intestinal brush border, guanylyl cyclase type C (GC-C). Intracellular cGMP is elevated, inducing increase in chloride efflux and subsequent accumulation of fluid in the intestinal lumen. We have screened a library of compounds and identifi...

In the title compound, C(13)H(12)N(2)OS, the dihedral angle between the aromatic rings is 14.84 (17)°. In the crystal, inversion dimers linked by pairs of N-H⋯O hydrogen bonds generate R(2) (2)(8) loops.

In the title compound, C(12)H(10)N(2)O(2)S, the dihedral angle between the benzene and thio-phene rings is 23.34 (16)°. In the crystal structure, mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds, forming (100) sheets.

In the title compound, C(12)H(9)BrN(2)OS, the dihedral angle between the aromatic rings is 10.0 (2)°. In the crystal structure, inversion dimers linked by pairs of N-H⋯O hydrogen bonds occur, generating R(2) (2)(8) loops. Weak aromatic π-π stacking [centroid-centroid separations = 3.825 (3) and 3.866 (3) Å] also occurs.

In the title compound, C(12)H(9)ClN(2)OS, the dihedral angle between the aromatic rings is 9.78 (11)°. In the crystal structure, inversion dimers linked by pairs of N-H⋯O hydrogen bonds occur, generating R(2) (2)(8) loops. Weak aromatic π-π stacking [centroid-centroid separations = 3.7210 (15) and 3.8706 (15) Å] also occurs.

In the title compound, C(12)H(10)N(2)O(3), the dihedral angle between the benzene ring and the furan ring is 16.12 (13)°. The conformation is stabilized by an intra-molecular O-H⋯N hydrogen bond. Inter-molecular N-H⋯O hydrogen bonds with the keto group as acceptor lead to strands along [001]. The mol-ecule displays a trans configuration with respect to the C=N and N-N bonds.