In studying the dynamics of the heart beat, the relationship between electrical and mechanical events in the cardiac cycle has been of fundamental importance. The basic concepts of this relationship have been defined by Lewis (1925) and Wiggers (1923) and their co-workers. Sir Thomas Lewis provided indirect information on these events in the right auricle of man. Animal experiments, supplemente...

The problem of pulse pile-up is very often encountered in precise measurements of γ-rays using germanium detectors. The standard method of treating the pile-up events is to identify and reject them using an appropriate electronic system. Digital acquisition techniques now allow the recording of waveforms of pile-up events that can be analyzed and the contributing single pulses recovered, rather...

BACKGROUND The role of pulsatile hemodynamics in the management of patients with acute heart failure syndrome (AHFS) remains to be elucidated. We investigated the changes of the pulsatile hemodynamics along the hospital course of AHFS in relation to short-term outcomes. METHODS A total of 80 AHFS patients (73.2 ± 14.1 years, 82.5% men) were enrolled and followed up for up to 6 months after di...

We report experimental results obtained from a chemical reaction-diffusion system in which wave propagation is limited to a finite band of wavelengths and in which no solitary pulses exist. Wave patterns increase their size through repeated annihilation events of the frontier pulse that allow the succeeding pulses to advance farther. A related type of wave dynamics involves a stable but slow fr...

We examined the initial effect of sleeping at a simulated moderate altitude of 2,650 m on the frequency of apneas and hypopneas, as well as on the heart rate and blood oxygen saturation from pulse oximetry (SpO2) during rapid eye movement (REM) and non-rapid eye movement (NREM) sleep of 17 trained cyclists. Pulse oximetry revealed that sleeping at simulated altitude significantly increased hear...

Carotid distensibility Arterial stiffness and wave reflection are now well-accepted as the most important determinants of increasing systolic and pulse pressures in ageing societies, thus promoting a major contribution to stroke and myocardial infarction. A major reason for measuring arterial stiffness and central pulse pressure (PP) in hypertensive patients comes from the demonstration that ar...

Primordial Black Holes (PBHs), which may have been created in the early Universe, are predicted to be detectable by their Hawking radiation. PBHs with an initial mass of ∼ 5×1014 g should be expiring today with a burst of high energy particles. Evaporating PBHs in the solar neighborhood are candidate Gamma-Ray Bursts (GRBs) progenitors. We propose spectral lag, which is the temporal delay betwe...

BACKGROUND Inverse associations between risk factors and mortality have been reported in epidemiological studies of patients on maintenance hemodialysis (MHD). OBJECTIVE The aim of this prospective study was to estimate the effect of the dual variable pulse pressure (PP) - body mass index (BMI) on cardiovascular (CV) events and death in type 2 diabetic (T2D) subjects on MHD in a Caribbean pop...

objective: experiencing ‎pleasant events during daily life ‎has a significant positive role in ‎the personal mental health and ‎acts as a keystone for “behavioral ‎activation” (ba) interventions. ‎there are serious differences in ‎the pleasant event schedules in ‎different cultures and countries. ‎we aimed to develop a persian ‎checklist of pleasant events ‎‎(pcpe) to provide and validate a ‎cu...

OBJECTIVE Hypertensive patients have an increased risk of developing diabetes. Accumulating evidence suggests a close relation between metabolic disturbance and increased arterial stiffness. Here, we examined the association between pulse pressure and the risk of new-onset diabetes in high-risk Japanese hypertensive patients. RESEARCH DESIGN AND METHODS The Candesartan Antihypertensive Surviv...