Abstract: Pulsatile flow in a 3D model of arterial double stenoses is investigated using a large eddy simulation (LES) technique. The computational domain that has been chosen is a simple channel with a biological-type stenosis formed eccentrically on the top wall. The pulsation was generated at the inlet using the first four harmonics of the Fourier series of the pressure pulse. The flow Reyno...

Dramatic changes in the shape of pulsatile ascending aortic pressure and flow wave forms occur during the Valsalva maneuver in man. To study these changes, aortic pressure and flow signals were recorded in eight patients using a multisensor catheter. Aortic input impedance was derived during the control, strain and postrelease phases of the Valsalva maneuver. During control, well-defined minima...

Hedgehog (Hh) signaling has recently been shown to be both responsive to mechanical loading in vitro and to control vascular development in vivo. We investigated the role of cyclic strain and pulsatile flow in modulating Hh signaling and growth of adult rat vascular smooth muscle cells (SMC) in culture. Exposure of SMC to defined equibiaxial cyclic strain (0% and 10% stretch, 60 cycles/min, for...

BACKGROUND AND PURPOSE Despite the importance of embolism as a major cause of brain infarction, little is known about the hemodynamic factors governing the path large emboli tend to follow. Our aim was to test in vitro, whether hemodynamic parameters other than flow ratios between bifurcation branches may affect the distribution of embolic particles in a Y-shaped bifurcation model, used as an a...

In this work, we investigate the behavior of the pulsatile blood flow in the system of human coronary arteries. Blood is modeled as an incompressible non-Newtonian fluid. The transient phenomena of blood flow through the coronary system are simulated by solving the three dimensional unsteady state Navier-Stokes equations and continuity equation. Distributions of velocity, pressure and wall shea...

The cardiovascular system is an internal flow network with multiple branches in which three-dimensional and pulsatile blood flow circulates. We propose a new paradigm of simulation-based biomedical engineering, which is designed as a useful means for predictive medicine. In order to achieve this paradigm a global computational modeling of cardiovascular blood flow is highlighted and some prelim...

The paper presents a numerical investigation of pulsatile blood flow in arterial vasculatures of a mouse retina using a Womersley model incorporating an appropriate outlet boundary impedance at the end of the terminal vessels of the arterial tree (pre-capillary arterioles). The mouse retinal flatmount was prepared for confocal microscopy and the morphometric information of the vasculature was o...

Normally, central elastic arteries (e.g., aorta and common carotid artery) effectively buffer cardiac pulsation-induced flow/pressure fluctuations. With advancing age, arterial stiffening deteriorates this function and produces the greater cerebral hemodynamic pulsatility that impacts vulnerable brain tissue. It is well known that the buffering function of the central artery is improved by regu...

Total left ventricular external power and aortic input impedance spectra were calculated from recordings of pulsatile pressure and flow in the ascending aorta of 22 human subjects undergoing cardiac catheterization. Eleven subjects had increased aortic pressure (systolic 153 +/- 3.8[SEM] mm Hg, p less than .001; diastolic 91 +/- 2.4 mm Hg, p less than .03; mean 118 +/- 2.4 mm Hg, p less than .0...