New oral anticoagulants have been shown to be not inferior to vitamin K antagonists in reducing thrombo-embolic events in patients with non-valvular atrial fibrillation and venous thrombo-embolism. However, those among them whichdirectly inhibit thrombin have been associated with greater risk of myocardial infarction. In this article we review the pleiotropic physiological effects of thrombin a...

OBJECTIVE: To determine the frequency of complications in patients suffering from chronic suppurative otitis media (CSOM). st th METHODS: This study was done in Saidu Sharif Teaching Hospital from 1 March 2010 to 30 June 2013. In this prospective studies 53 patients of Chronic suppurative otitis media were selected. RESULTS: In our study 31(58.4%) male and 22 (41.5%) were female. Age distributi...

from peripheral blood leukocytes as described previously (5). Amplification of genomic DNA was performed by PCR as described (1). The G3 A substitution at nucleotide position 20210 was detected by allele-specific restriction digestion by using HindIII (1). Among the 27 patients, 4 (14.8%) were heterozygous for the G 20210 3 A mutation in the prothrombin gene and 1 patient (3.7%) was homozy-gous...

Two cases of ha-mophilus influenzameningitis have been described who showed lack of response to the routine antibiotics. These two cases did not respond to the oral Penbritin because of vomiting and were treated with intramuscular and intrathecal Penbritin with successful results as shown by biochemical and clinical responses. It should be stressed that neither of these preparations of Penbriti...

A percutaneous coronary intervention presents unique challenges to the antithrombotic management of patients requiring chronic anticoagulation. Warfarin is often discontinued several days before a percutaneous intervention, exposing patients to the risk of potentially life-threatening thrombo-embolic complications. In contrast, bridging the period after the intervention until a therapeutic INR ...