Pulmonary surfactant functions by first flowing rapidly into the alveolar air/water interface, but then resisting collapse from the surface when the adsorbed interfacial film is compressed during exhalation. Widely accepted models emphasize the importance of phase behavior in both processes. Recent studies show, however, that fluidity is a relatively minor determinant of adsorption and that sol...

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Surfactant-templating is one of the most versatile and useful techniques to implement mesoporous systems into solid materials. Various strategies based on various interactions between surfactants and solid precursors have been explored to produce new structures. Zeolites are invaluable as size- and shape-selective solid acid catalysts. Nevertheless, their micropores impose limitations on the ma...

Monolayer surfactant films composed of a mixture of phospholipids and perfluorinated (or partially fluorinated) surfactants are of potential utility for applications in pulmonary lung surfactant-based therapies. As a simple, minimal model of such a lung surfactant system, binary mixed monolayer films composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and perfluorooctadecanoic acid (...

Wood, Philip G., Olga V. Lopatko, Sandra Orgeig, Jonathan R. Codd, and Christopher B. Daniels. Control of pulmonary surfactant secretion from type II pneumocytes isolated from the lizard Pogona vitticeps. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1705–R1711, 1999.—Pulmonary surfactant, a mixture consisting of lipids and proteins and secreted by type II cells, functions to...

The COVID-19 pandemic is still raging all over the world. New variants of coronavirus emerge and infect recovered from previous infections, vaccinated, unvaccinated subjects. One aspect remains unchanged that lungs are main targets coronavirus. This challenging situation requires search for reliable predictive markers severe complicated course disease. Serum surfactant proteins known to correla...

Advances in the physiology, biochemistry, molecular and cell biology of the pulmonary surfactant system transformed the clinical care and outcome of preterm infants with respiratory distress syndrome. The molecular era of surfactant biology provided genetic insights into the pathogenesis of pulmonary disorders, previously termed 'idiopathic', that affect newborn infants, children and adults. Kn...

Bacterial pneumonia remains a significant cause of patient morbidity and mortality worldwide. Pulmonary surfactant serves to maintain homeostasis in the lung through the maintenance of alveolar stability and the regulation of the alveolar immune response. The purpose of this study was to characterize the lung injury and associated surfactant alterations in a rat model of acute Pseudomonas aerug...

• The surface tension of extracts from normal lungs is extremely low owing to the presence of a specific surfactant. Experiments of Finley et al. showing an abnormally high surface tension of lung extracts obtained 12 to 16 hours after ligation of the pulmonary artery (PA) were confirmed by Long and associates. These studies suggested that the surfactant is decreased or absent after PA ligation.

Pulmonary surfactant controls the surface tension at the air-liquid interface within the lung. This system had a single evolutionary origin that predates the evolution of the vertebrates and lungs. The lipid composition of surfactant has been subjected to evolutionary selection pressures, particularly temperature, throughout the evolution of the vertebrates.