Ion channels/pumps are essential regulators of organ homeostasis and disease. In the present review, we discuss the role of the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), in cytokine secretion and pulmonary inflammatory diseases such as asthma, cystic fibrosis (CF), and acute lung injury/acute respiratory distress syndrome (ARDS). TRPV4 has been shown to ...

This article reviews the pulmonary route of administration, aerosol delivery devices, characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled delivery of siRNA. Diseases with known protein malfunctions may be mitigated through the use of siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics for the treatment...

PEOPLE WITH CYSTIC FIBROSIS (CF) are surviving in larger numbers into adulthood and even middle age. Over time, acquisition of antibiotic-resistant gram-positive and gram-negative bacteria in the airways leads to progressive inflammation and cycles of pulmonary exacerbations that drive obstructive lung disease and decline in lung function. CF patients have an exuberant immune system aided by ev...

Pulmonary drug disposition after inhalation is complex involving mechanisms, such as regional drug deposition, dissolution, and mucociliary clearance. This study aimed to develop a systems pharmacology approach to mechanistically describe lung disposition in rats and thereby provide an integrated understanding of the system. When drug- and formulation-specific properties for the poorly soluble ...

tracheomegaly or tracheobronchomegaly is a rare syndrome which is characterized by dramatic dilatation of the trachea and the major bronchi. this syndorme is usually associated with chronic respiratory infection and airway obstruction. in this paper, a case with tracheomegaly and bronchiectasis was scrutinized.