This Viewpoint discusses the intersection of targeted protein degradation (TPD) technologies and psychedelic research. The resurgence in interest psychedelics for treating mental disorders known genetic variability responses require new strategies. TPD might address this variability, modulating expressions based on profiles. discussion includes potential challenges implementing research strateg...

Over the past decade and a half, psychedelic drug-induced experiences have been returning to psychiatry as promising new healing modalities. The case of psychedelic-assisted psychotherapy can inform how we think about context drug use because psychedelics are commonly considered be sensitive ‘[mind]set setting’ their use. As such, epistemic therapeutic concerns amongst researchers therapists ov...

Abstract Background and aims Most modern modalities of psychedelic-assisted psychotherapy (PAP) aim to minimize harm maximize support by utilizing close, formalized supervision for a single participant per session. However, these substances are used naturalistically in wide variety settings. Our goal was evaluate the perceived benefits harms naturalistic psychedelic use diverse settings, with w...

Existential, neurobiological and cognitive models of addictive behavior are considered as a theoretical basis for transformational therapy disorders. The NMDA receptor antagonist ketamine, which has neurotrophic, modulatory psychedelic effects, demonstrates the universal properties transforming agent any presented concepts behavior. Since persistent mental behavioral changes essentially psychob...

Red fly agaric poisoning is rare. It can be consumed for suicidal purposes or its psychedelic effect. The paper describes the case of a young men, who fell into a coma after ingestion of the red toadstools. Quick identification of the poison, early use of gastric lavage and symptomatic treatment resulted in regression of symptoms and lead to the patient's discharge from the hospital on the thir...

Introduction Curiosity toward the effects of psychedelic drugs on neural activation has increased due to their potential therapeutic benefits, particularly serotonergic psychedelics that act as 5-HT2A receptor agonists such LSD, psilocybin, and MDMA. However, pattern activity in various brain regions both clinical healthy populations is still not well understood, primary studies addressing this...

In a recent study Garfield (1975) found that psychedelic drug users, Zen meditators, and practitioners of Tibetan Buddhism expressed more accepting attitudes toward death than did graduate students in both psychology and religion; also, that Zen and Tibetan Buddhists were more accepting than the drug users. Garfield suggested that states of altered awareness, achieved through the use of drugs o...