THE GROUP of diseases characterized by McKusick as generalized "heritable disorders of connective tissue" includes the Marfan syndrome, the Ehlers-Danlos syndrome, osteogenesis imperfecta, the Hurler syndrome, and pseudoxanthoma elasticum. With the exception of osteogenesis imperfecta, all of these have been known to involve significant cardiovascular abnormalities.' The Marfan syndrome is freq...

s of South West Vascular Surgeons Meeting held at St. Mary's Hospital, Portsmouth, 14 February 1992 PSEUDOXANTHOMA ELASTICUM CAUSING CLAUDICATION. W. G. Prout. Queen Alexandra Hospital, Portsmouth. Pseudoxanthoma elasticum is a heritable disorder of elastic fibre leading to characteristic skin changes, angioid occular streaking and cardio-vascular problems. A 34 year old man presenting with int...