نتایج جستجو برای: proviruses

تعداد نتایج: 963  

Journal: :The Journal of clinical investigation 2016
Ariel Halper-Stromberg Michel C Nussenzweig

Current antiretroviral drug therapies do not cure HIV-1 because they do not eliminate a pool of long-lived cells harboring immunologically silent but replication-competent proviruses - termed the latent reservoir. Eliminating this reservoir and stimulating the immune response to control infection in the absence of therapy remain important but unsolved goals of HIV-1 cure research. Recently disc...

Journal: :Environmental Health Perspectives 1990
H von Melchner H E Ruley

By exploiting the ability of retroviruses to move genes into random sites of mammalian genomes and by exploiting some features of their replication, retrovirus vectors have been developed that select for instances in which the virus integrates into expressed genes. Since integrated proviruses tag transcriptionally active sites, the vectors provide a means to identify and isolate promoters activ...

Journal: :Journal of virology 2001
G J Baillie R J Wilkins

We have sequenced and characterized an endogenous type D retrovirus, which we have named TvERV(D), from the genome of an Australian marsupial, the common brushtail possum (Trichosurus vulpecula). Intact TvERV(D) gag, pro, pol, and env open reading frames were detected in the possum genome. TvERV(D) was classified as a type D retrovirus, most closely related to those of Old World monkeys, New Wo...

2016
Hirotaka Ebina Peter Gee Yoshio Koyanagi

BACKGROUND Current HIV antiretroviral therapies potently suppress virus replication and prevent patients from progressing to AIDS but are unable to completely eliminate HIV due to the existence of dormant viral reservoirs which threaten to reemerge at anytime. Recently, genome-editing technologies that can recognize specific DNA sequences, including viral DNA, are being touted as promising tool...

2014
James A. Shapiro

Mobile DNA in the genome is subject to RNA-targeted epigenetic control. This control regulates the activity of transposons, retrotransposons and genomic proviruses. Many different life history experiences alter the activities of mobile DNA and the expression of genetic loci regulated by nearby insertions. The same experiences induce alterations in epigenetic formatting and lead to trans-generat...

Journal: :Nucleic acids research 1985
J Hauber P Nelböck-Hochstetter H Feldmann

We have determined the nucleotide sequence of a complete yeast Ty element (Ty-pY109) which is located near a tRNA(Lys1) gene. The element is 5912 bp in length; the internal domain is flanked by two identical delta sequences of 331 bp. Ty-pY109 contains two large open reading frames (ORFs) which overlap by 38 bp; the putative proteins consist of 440 and 1328 amino acid residues, respectively. Th...

2015
S.-K. Lee S. Zhou N. Archin D. Margolis R. Swanstrom

Background: Viral outgrowth assay (VOA) is a widely used culture assay to measure the latent HIV-1 reservoir harboring replication-competent HIV-1 in resting CD4+ T cells in patients on HAART. However, the assay is costly, and both labor and resource intensive. To overcome some of these issues with the VOA, we designed an assay using ultra deep sequencing (UDS), which directly analyzes the numb...

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