The majority of human coding regions have been sequenced and several genome sequencing projects have been completed. With the growth of large-scale sequencing data, an efficient approach to analyze protein is more important. Protein function and structure are foundations for drug design and protein-based product. However, it’s difficult to predict protein function and structure (three-dimension...

a thorough recognition of the nature and duties of the genes is based upon having adequate information about the proteins. however, the proteomic projects follow a slow trend; therefore, solving the protein-related problems has become as one of the most important challenges in bio-informatics. consequently, the presence of tools which can enhance the structural recognition, classification, and ...

A strong similarity between the major aspects of protein folding and protein recognition is one of the emerging fundamental principles in protein science. A crucial importance of steric complementarity in protein recognition is a well-established fact. The goal of this study was to assess the importance of the steric complementarity in protein folding, namely, in the packing of the secondary st...

Betatrophin is a member of the angiopoietin-like (ANGPTL) family that has been implicated in both triglyceride and glucose metabolism. The physiological functions and molecular targets of this protein remain largely unknown; hence, a purified available protein would aid study of the exact role of betatrophin in lipid or glucose metabolism. In this study, we cloned the full-length cDNA of betatr...

Protein secondary structure prediction is a problem related to structural bioinformatics which deals with the prediction and analysis of macromolecules i.e. DNA, RNA and protein. It is an important step towards elucidating its three dimensional structure, as well as its function. Secondary structure of a protein can be predicted from its primary structures i.e. from the amino

The development of low-molecular-weight agents that modulate protein–protein interactions has been regarded as a difficult goal due to the relatively large and featureless protein interfacial surfaces involved [1–3]. Conventional methods for identifying inhibitors of protein–protein interactions generally involve the preparation and screening of large chemical libraries to discover lead compoun...

Protective antigen (PA), a subunit of anthrax toxin from Bacillus anthracis, is known as a dominant component in subunit vaccines in protection against anthrax. In order to avoid the side effects of live attenuated and killed organisms, the use of linear neutralizing epitopes of PA is recommended in order to design recombinant vaccines. The present study is aimed at determining the dominant epi...