BACKGROUND In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by which IgE up-regulates cell proliferation and extracellular matrix deposition by human airway smooth muscle cells in asthma is unclear. OBJEC...

self-assembly of densely packed zno nanorods were grown on porous silicon (ps) substrate by low-temperature chemical bath deposition. the structural and optical properties of the obtained zno nanostructures on ps substrate were systematically studied. the strong and sharp (002) peak compared with other peaks in the x-ray diffraction (xrd) indicated thatzno nanorods formed with superior orientat...

despite having some useful properties, stainless steels suffer from lack of suitable surface hardness. in this research electroless ni-b-tl coating was used with the aim to increase their surface hardness. the effects of nickel chloride, sodium borohydride, thallium nitrate and ethylendiamin on the chemical composition of coating were studied. to achieve an increase in hardness, the effects of ...

Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflammation before presenting, most commonly with renal involvement. Using dose-dep...

Evidence indicates a critical role for cerebrovascular dysfunction in Alzheimer’s disease (AD) pathophysiology. We have shown that fibrin(ogen), the principal blood-clotting protein, is deposited in the AD neurovasculature and interacts with beta-amyloid (Ab), resulting in increased formation of blood clots. As apolipoprotein E (ApoE), a lipid-transporting protein with three human isoforms (E2,...

Candida albicans is an opportunistic fungal pathogen that poses a serious threat to immunocompromised patients. Candida’s greatest mechanism of defense against the host immune system is its cell wall. It has been shown that chitin, a component of Candida’s cell wall, is synthesized during cellular stress. We investigated the temporal dynamics of chitin deposition during immune attack by perform...

Direct immunization with amyloid protein (A ) and passive transfer of anti-A antibodies reduce A accumulation and attenuate cognitive deficits in transgenic models of Alzheimer’s disease (AD). The reduction in A deposition has been proposed to involve microglial phagocytosis of A immune complexes via Fc receptors (FcRs). We have examined the efficacy of A immunization in amyloid precursor prote...

The corrosion of CoCrMo, an alloy frequently used in orthopedic implants, was studied with an electrochemical quartz crystal microbalance (QCM) in three physiologically relevant solutions. Mass changes were measured during potentiodynamic tests, showing material deposition in protein solutions at potential levels that caused mass loss when the proteins were not present. X-ray photoelectron spec...

The glomerulofibrotic Col1a2-deficient mouse model demonstrates glomerular homotrimeric type I collagen deposition in mesangial and subendothelial spaces. In this report, we investigate the role of transforming growth factor β1 (TGF-β1) in myofibroblast activation and epithelial-mesenchymal transition (EMT) in this glomerulopathy. Immunohistochemical analyses of glomerular α-sma, desmin, viment...

Tribulus terrestris herb has been used as a drug in traditional medicine and its toxic effects have also been reported. Less attention has been paid to the interpretation of pathological and laboratory findings in the natural form poisoning with this plant in animals. Following a report of mortalities in a sheep farm feeding on a pasture containing Tribulus terrestris herb and involvement of 50...