The purpose of the study was to determine the relevance of protein S deficiency in HIV infected patients with ischaemic stroke. In total, 33 HIV positive patients with ischaemic stroke, previously described by us, were prospectively compared with control groups for occurrence of protein S deficiency. The control groups comprised an equal number of consecutive matched HIV positive and negative p...

Measurement of Protein S in human plasma is clinically important because of deficiency of this protein, which functions as a cofactor of the naturally occurring anticoagulant activated Protein C, is a risk factor for venous thromboembolism. We describe a two-site, enzyme-linked immunosorbent assay (ELISA) for measuring Protein S in which a monoclonal IgG directed against the calcium-independent...

Plasma protein-C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism. However, arterial thrombosis occurring as a resu...

Protein C (PC) is an essential vitamin K-dependent protein that regulates thrombosis and hemostasis in the body. A mutation PROC gene on chromosome 2q14.3 results PC deficiency. The clinical presentation of deficiency can vary, ranging from a single vein to disseminated intravascular coagulation, purpura fulminans, or even life-threatening complications such as sepsis. Here, we present case 37-...

abstract       background and objectives: diabetes induced oxidative stress plays an important role in pathological damage to the heart and liver by increased production of extracellular matrix. it is thought that the use of medicinal plants, particularly portulaca oleracea. l and regular exercise are effective. the aim of this study was to evaluate the effects of portulaca oleracea. l consumpt...

Background and purpose: Deficits of protein C S are associated with an increased incidence thrombotic disorders. The aim the present study was to determine levels mentioned natural coagulation inhibitors in women preeclampsia a 6-months followup period after delivery.Materials methods: This case-control clinical included 55 pregnant (cases) 50 healthy normotensive (controls) tertiary perinatal ...

BACKGROUND Little research has been performed regarding the psychological consequences of knowing that one is at an increased risk for venous thrombosis. OBJECTIVES The aim of this study was to explore attitudes toward genetic testing for protein C deficiency. METHODS Questionnaires about genetic testing attitudes, dispositional anxiety, risk perception, and thrombosis-related worry were co...