This paper by Wood and Werkman is truly outstanding. First, it is a classical example of determination of the path of a fermentation by careful quantitative analyses of substrates consumed and products formed. Second and most importantly, the results led to the discovery of CO2 fixation by heterotrophic bacteria. The dogma at the time the work was done and as expressed in textbooks held that on...

In a paper dealing with the nutrition of the propionic-acid bacteria Wood, Andersen, and Werkman (1938) report that one species Propionibacterium pentosaceum (49W), can be "trained" to grow as well in the absence of vitamin B1 as in its presence. Their data show that adaptation occurred after continuous serial transfer in an ammonium sulfate medium containing only ether extract of yeast extract...

Over the last three decades, there has been a resurgence of interest in large-scale production of fermentation chemicals due to the sharp increase in petroleum cost. So the potential role of a new energy efficient fermentation technology is receiving growing attention. Propionic acid is widely used in the food, pharmaceutical and chemical industries. Fermentation technology for the production o...

The potential of recovering propionic acid from discharged water in vitamin B(12) production by anaerobic fermentation was investigated in this paper. A primary amine, N(1923), was used as the extractant, kerosene as diluter and n-octanol as modifier. The influences of the content of N(1923) in the organic phase, the phase ratio and the pH of aqueous phase on the extraction yield of propionic a...

We developed an ion-exclusion/adsorption chromatography (IEAC) method employing a polystyrene-divinylbenzene-based weakly acidic cation-exchange resin (PS-WCX) column with propionic acid as the eluent for the simultaneous determination of multivalent aliphatic carboxylic acids and ethanol in food samples. The PS-WCX column well resolved mono-, di-, and trivalent carboxylic acids in the acidic e...

Direct β-carbon activation of propionic acid (C2H5CO2H) by carbene organocatalysis has been developed. This activation affords the smallest azolium homoenolate intermediate (without any substituent) as a 3-carbon nucleophile for enantioselective reactions. Propionic acid is an excellent raw material because it is cheap, stable, and safe. This approach provides a much better solution to azolium ...

The processes of extractive distillation and heteroazeotropic mixtures containing water a high-boiling component (propionic acid, acetic 1-methoxy-2-propanol) are compared. Entrainers declared in the literature as effective agents for these were selected separating agents. A process simulation AspenPlus V.11.0 is made. Parametric optimization carried out column operation parameters (number stag...

Arthrobacter sp. strain NO-18 was first isolated from soil as a bacterium which could degrade the sodium acrylate oligomer and utilize it as the sole source of carbon. When 0.2% (wt/wt) oligomer was added to the culture medium, the acrylate oligomer was found to be degraded by 70 to 80% in 2 weeks, using gel permeation chromatography. To determine the maximum molecular weight for biodegradation...