In 2014, I was on the Board of Directors of the Society of Urologic Oncology (SUO) when Merck announced having shortages of Tice strain Bacillus Calmette Guerin (BCG), a critical “drug” for treating intermediate and particularly high risk non-muscle invasive (NMI) urothelial cancer (UC) of the bladder, including carcinoma-in-situ (CIS) and high-grade (HG), stage Ta and T1 disease after transure...

1 Parke-Davis Pharmaceutical Research, Ann Arbor, MI, 2 Stadtlander Drug Company Inc., and University of Pittsburgh, Pittsburgh, PA, 3 Ohio State University, Columbus, OH, 4 University of Wisconsin Hospitals & Clinics, Southfield, MI, 5 University of Arizona College of Pharmacy, Tucson, AZ, 6 Indiana University, Bloomington, IN, 7 Merck Research Laboratories, Blue Bell, PA, 8 University of Sout...

Healthcare, Astellas, Merck, Sanofi Aventis, BMS/Pfizer, Daiichi Sankyo, Biotronik, Medtronic, Portola and Boehringer Ingelheim and has been on the speakers bureau for Bayer Healthcare, BMS/Pfizer, Boehringer Ingelheim, Daiichi Sankyo, Medtronic and Sanofi Aventis. G.A. reports personal fees that were outside the submitted work from Bayer Healthcare, Boehringer Ingelheim, BMS, Daiichi Sankyo, S...

The much-publicised halting of the joint Merck/HIV Vaccine Trials Network phase IIB candidate HIV-1 vaccine trial in 2007 has led to an unprecedented degree of discussion and introspection amongst the HIV research community. In this commentary, we will summarise the lessons learned from the trial and examine the current state of HIV vaccine research.

HPLC methods have been developed for the assay of bisacodyl in various pharmaceutical forms. The extraction procedures are simple and the HPLC conditions separate bisacodyl from its degradation products. The chromatography was performed using a Merck LiChrospher RP-select B column, a mobile phase of 55% acetonitrile/45% 0.05 M KH2PO4 and detection by UV at 214 nm.

Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania (D.C., P.J.H.); Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania (D.C.); and Department of Pharmacology, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia (G.O.R.) DMD Fast Forward. Pu...

INTRODUCTION Since Pall-German stopped manufacturing ITLC-SG, it has become necessary to validate alternative stationary phases. OBJECTIVE To validate different stationary phases versus ITLC-SG Pall-Gelman in the determination of the radiochemical purity (RCP) of (111)In-pentetreotide ((111)In-Octreoscan) by planar chromatography. MATERIAL AND METHODS We conducted a case-control study, whic...

Ivermectin was a revolutionary drug in the 1980s, the forerunner of a new group of antiparasitic agents with activity against both parasitic nematodes and arthropods. Initially it was marketed for veterinary use by Merck & Co. Inc.; it was used largely for nematode control in cattle, horses, pigs and dogs and became the standard for control of the ectoparasitic disease, scabies. The injectable ...

SHAO-SHAN HUANG,1,2,∗ DEBRA L. FULTON,1,2,∗ DAVID J. ARENILLAS, PAUL PERCO, SHANNAN J. HO SUI, JAMES R. MORTIMER AND WYETH W. WASSERMAN Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, Canada Department of Nephrology, Medical University of Vienna, Vienna, Austria Merck Frosst Centre fo...

Anthony D. WHETTON,*§ Susan J. VALLANCE,* Peter N. MONK,* Edward J. CRAGOE,4 T. Michael DEXTERt and Clare M. HEYWORTHt *Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, Manchester M60 IQD, U.K., tExperimental Haematology Section, Paterson Institute, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K., and 4...