Taste and oral sensations vary in humans. Some of this variation has a genetic basis, and two commonly measured phenotypes are the bitterness of propylthiouracil (PROP) and the number of fungiform papillae on the anterior tongue. While the genetic control of fungiform papilla is unclear, PROP bitterness associates with allelic variation in the taste receptor gene, TAS2R38. The two common allele...

Cardiac microvascular rarefaction appears to be involved in hyperthyroidism-induced left ventricular hypertrophy and dysfunction. We investigated the effects of losartan, an AT1 receptor antagonist; diltiazem, a calcium channel blocker; and propranolol, a β-adrenergic receptor antagonist, on cardiac function and structural microcirculatory cardiac alterations in an experimental model of l-thyro...

The G protein-coupled receptor (GPCR) TAS2R38 is a bitter taste receptor that can respond to bitter compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). This receptor was chosen because its four haplotypes (based on three residue site polymorphism) hTAS2R38PAV, hTAS2R38AVI, hTAS2R38AAI, and hTAS2R38PVV are known to have dramatically different responses to PTC and PROP. W...

The intrinsically disordered regions of eukaryotic proteomes are enriched in short linear motifs (SLiMs), which are of crucial relevance for cellular signaling and protein regulation; many mediate interactions by providing binding sites for peptide-binding domains. The vast majority of SLiMs remain to be discovered highlighting the need for experimental methods for their large-scale identificat...

Fast learning under incremental learning environments is very important in real situations as data are generated rapidly over time. However, the input-output relationships that are trained before tend to be destroyed when new data are received. Therefore, the information on the previous data tends to be lost when the data are drawn from the different data distribution. This phenomenon is called...

We show how model checking techniques can be applied to the analysis of connectivity and cost of traversal prop erties of Web sites

Perceived intensities of sweetness and bitterness are correlated with one another and each is influenced by genetics. The extent to which these correlations share common genetic variation, however, remains unclear. In a mainly adolescent sample (n = 1901, mean age 16.2 years), including 243 monozygotic (MZ) and 452 dizygotic (DZ) twin pairs, we estimated the covariance among the perceived inten...

The present study aimed at verifying the usefulness of dietary 2.5% bee-pollen (BP) or propolis (PROP) to overcome the genotoxic and endocrine disruptive effects of malathion polluted water in Oreochromis niloticus (O. niloticus). The acute toxicity test was conducted in O. niloticus in various concentrations (0-8 ppm); mortality rate was assessed daily for 96 h. The 96 h-LC50 was 5 ppm and the...

OBJECTIVES Eating behaviors and obesity are complex phenotypes influenced by genes and the environment, but few studies have investigated the interaction of these two variables. The purpose of this study was to use a gene-environment interaction model to test for differences in children's food acceptance and body weights. DESIGN AND METHODS Inherited ability to taste 6-n-propylthiouracil (PRO...

In this paper, we are concerned with the classification problem of proper holomorphic maps between balls in complex spaces. Write Bn = {z ∈ Cn : |z| < 1} and Prop(Bn,BN ) for the collection of all proper holomorphic maps from Bn into BN . We recall that f, g ∈ Prop(Bn,BN ) are said to be equivalent if there are elements σ ∈ Aut(Bn) and τ ∈ Aut (BN ) such that f = τ ◦ g ◦ σ . It is a well-known ...