نتایج جستجو برای: promotion of autophagy

تعداد نتایج: 21177684  

Background and Aim: Infertility in men is 10-20% of cases due to azoospermia. The aim of this study was to investigate the effect of swimming training, cell and laser on the expression of genes involved in autophagy (LC3 and Beclin-1) in azoospermia mice. Methods: 30 rats 6 to 8 weeks of age were randomly selected from Tehran Laboratory Animal Research and Propagation Center, and then injected ...

F. Chen, H. Chen, H. Zhang, J. Feng, P. Liu, X. Hu, X. Zhang, Y. Miao, Z. Liu, Z. Zhou,

ABSTRACT Background: Tumor cells exhibit an increased requirement for iron to support their rapid proliferation. Deferoxamine (DFO), an iron chelator, has been reported to have anti-proliferative effects on cancer cells through induction of apoptosis and cell cycle arrest. X-rays also induce apoptosis and cell cycle arrest. However, limited information is available regarding the effect of iron...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Zhiyuan Zhu Jianming Yan Wei Jiang Xin-gang Yao Jing Chen Lili Chen Chenjing Li Lihong Hu Hualiang Jiang Xu Shen

Alzheimer's disease (AD) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. The β-amyloid (Aβ)-induced neurodegeneration is believed to be the main pathological mechanism of AD, and Aβ production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-AD researc...

2017
Li-Qiang Zheng Su-Min Chi Cheng-Xin Li

Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. Rab23 is also a negative regulator of the Sonic hedgehog (Shh) signaling pathway in an indirect way. The nonsense mutation and loss of protein of Rab23 has been associated with neural tube defect in mice and aberrant expression in various diseases in human such as neural system, breast, visce...

Journal: :Plant physiology 2014
Yan Xiong Jen Sheen

The target of rapamycin (TOR) kinase, a master regulator that is evolutionarily conserved among yeasts (Saccharomyces cerevisiae), plants, animals, and humans, integrates nutrient and energy signaling to promote cell proliferation and growth. Recent breakthroughs made possible by integrating chemical, genetic, and genomic analyses have greatly increased our understanding of the molecular functi...

Journal: :Theranostics 2021

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and invading pathogens via the lysosomal system (the vacuole in plants yeast). Autophagy generally induced by stress, such as oxygen-, energy- amino acid-deprivation, irradiation, drugs, etc. In addition to non-selective bulk degrada...

Journal: :Molecular cancer therapeutics 2015
Lauryn R Werner Shyhmin Huang David M Francis Eric A Armstrong Fang Ma Chunrong Li Gopal Iyer Jude Canon Paul M Harari

MDM2-p53 interaction and downstream signaling affect cellular response to DNA damage. AMG 232 is a potent small molecule inhibitor that blocks the interaction of MDM2 and p53. We examined the capacity of AMG 232 to augment radiation response across a spectrum of human tumor cell lines and xenografts. AMG 232 effectively inhibited proliferation and enhanced radiosensitivity via inhibition of dam...

2017
Ana B. Sanchez Marcus Kaul

Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND), which occur despite the successful introduction of combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH), se...

2014
Yan Xiong

The target of rapamycin (TOR) kinase, a master regulator that is evolutionarily conserved among yeasts (Saccharomyces cerevisiae), plants, animals, and humans, integrates nutrient and energy signaling to promote cell proliferation and growth. Recent breakthroughs made possible by integrating chemical, genetic, and genomic analyses have greatly increased our understanding of the molecular functi...

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