Monoclonal free light chains are found in the serum and urine of patients with B-cell proliferative disorders, including multiple myeloma. Measuring free light chains in serum is useful for the diagnosis and monitoring of free light chains diseases. Moreover it could be interesting in the monitoring of treated multiple myeloma with complete immunoglobulin and of monoclonal gammapathy of undeter...

Mitogen-induced transformation and the production of reactive oxidants by mononuclear leucocytes (MNLs) from patients with chronic dermatological disorders were investigated in vitro before and during the administration of the antimycobacterial/immunosuppressive agent clofazimine (200 mg 3 times weekly). Seven patients, 4 with lichen planus and 3 with cutaneous lupus erythematosus, were include...

A 52 year old man with newly diagnosed polycythaemia vera in proliferative phase developed widespread extramedullary haemopoiesis (EMH), and died as a result of cervical cord compression. At necropsy, microscopic areas of primitive cells characteristic of granulocytic sarcoma were found within a large tumour of EMH in the right retroperitoneal region. Ultrastructural analysis showed unusual hex...

Adult oligodendrocyte progenitor cells are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential during health and disease. Recently, developments in new experimental approaches have brought about several novel insights about NG2-glia and myelinating oligodendrocytes, indicating a diverse toolkit of functions in experience-dependent myelina...

Hematopoietic neoplasia is a large and diverse group of clonal proliferative disorders of hematopoietic cells. The most common hematopoietic malignancy in dogs is lymphoma. While multicentric, large cell lymphoma represents the most common clinical presentation, lymphoma can affect a wide range of organ systems, causing a variety of clinical signs. The multicentric lymphoma that we see in our c...

OBJECTIVE The main objective was to investigate the effect of linguistic abilities (lexical-access ability and vocabulary size) on different measures of speech-in-noise recognition in normal-hearing listeners with various levels of language proficiency. DESIGN Speech reception thresholds (SRTs) were measured for sentences in steady-state (SRTstat) and fluctuating noise (SRTfluc), and for digi...

PURPOSE. The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healing conditions. The matrix metalloproteinases (MMPs) are a family of enzymes that degrade and remodel the extracellular matrix and, thus, play a central role in the wound-healing process. Proliferative vitreore...

Antipsychotic drugs are widely used to alleviate a number of psychic disorders and have been found to modulate some immune parameters, but the molecular mechanism of their action on the proliferative activity has been poorly recognized. In the present study, we investigated effects of various antipsychotics on the proliferative activity of lymphocytes stimulated by concanavalin A (Con A) and li...

Background: uncontrolled cell proliferation of the ocular blood network is one leading causes blindness and low vision worldwide. We summarize relevant published data our 5-year experience in searching treatment tools for excessive non-productive proliferation. Aim: to describe genetic patterns patients with predicting disease course selecting adequate treatment. Patients Methods: 1210 prolifer...