1) The evidence for a role of prolactin in the premenstrual syndrome is discussed in this review. (2) The timing of the onset and offset of both physical and psychological dysphoric symptoms corresponds with the luteal elevation and menstrual decrease of serum prolactin levels. (3) Women with premenstrual symptoms have been shown to have high prolactin levels throughout the menstrual cycle and ...

Since anterior pituitary expresses prolactin receptors, prolactin secreted by lactotropes could exert autocrine or paracrine actions on anterior pituitary cells. In fact, it has been observed that prolactin inhibits its own expression by lactotropes. Our hypothesis is that prolactin participates in the control of anterior pituitary cell turnover. In the present study, we explored the action of ...

Abstract The molecular evolution of pituitary growth hormone and prolactin in mammals shows two unusual features: episodes markedly accelerated and, some species, complex families related proteins expressed placenta resulting from multiple gene duplications. Explanations these phenomena terms physiological adaptations seem unconvincing. Here, I propose an alternative explanation, namely that ev...

BACKGROUND Animal models and experimental studies suggest a role for paracrine prolactin (PRL) signalling in decidualization and embryo implantation. We investigated the expression of endometrial prolactin (e-PRL) and prolactin receptor (PRL-R) in the endometrium of women affected by unexplained infertility (UI) and repeated miscarriages (RM). METHODS Patients (n = 24) were divided into three...

PURPOSE We have previously shown that transgenic mice ubiquitously overexpressing the HMGA2 gene develop growth hormone/prolactin-secreting pituitary adenomas. This animal model has been used to evaluate the therapeutic efficacy of SOM230, a somatostatin analogue with high affinity for the somatostatin receptor subtypes 1, 2, 3, and 5, on the growth of the pituitary adenomas. EXPERIMENTAL DES...

prophet of pou1f1 (prop1) plays direct or indirect important roles in the morphogenesis of pituitary gonadotropes as well as lactotropes, somatotropes and caudomedial thyrotropes. it also controls the expression of growth hormone, prolactin and thyrotropin subunits through regulatory pit1 factor. these hormones have important influences on production traits in most animal species including the ...

Pituitary prolactin has been quantified by radioimmunoassay in whole milk obtained from cattle, goats, sheep and rats. Prolactin concentrations in milk samples obtained following the completion of lactogenesis approximate concentrations of the hormone in blood plasma or serum. However, concentrations of prolactin in prepartum mammary secretions were much higher than plasma prolactin in prepartu...

Objetives. To determine the correlation between prolactin levels and disease activity classified based on Mexican lupus erythematosus systemic index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well manifestations of active were determined. Disease was evaluated using Systemic Lupus Erythematosus Activity Index (MEX-S...

Hyperprolactinaemia is one of the most frequent causes anovulation, resulting in infertility and hypoestrogenic state with consequences on overall women’s health. Recent investigations biological actions prolactin, especially prolactin extrapituitary origin, expand our knowledge role human organism open new questions connected female reproductive function treatment infertility. This article rep...

Familial Isolated pituitary adenoma (FIPA) is a rare cause of and underscores the importance family history knowledge screening guidelines in these patients. A 26-year-old female presented with secondary amenorrhea, galactorrhea, headaches dizziness. Labs showed Prolactin 501 ng/ml (3.3-26.7 ng/mL) IGF 391 (96-301 ng/mL). MRI brain 12 x 14 15 mm mass. Acromegaly was confirmed glucose suppressio...