The scope of the problem of the management of pregnancies occurring in women with pituitary disease is indicated by the fact that 20% ofnon-pregnant women with amenorrhoea have hyperprolactinaemia and 40% of women with hyperprolactinaemia have pituitary tumours (Franks et al., 1975). We concentrate therefore on disturbance of prolactin secretion and discuss other pituitary diseases only briefly...

Prolactin, an anterior pituitary hormone, has been shown to have a role in immunomodulation. Some reports have shown the importance of prolactin in activating lymphocytes and macrophages, while in hyperprolactinemia patients, prolactin was found to decrease lymphocyte activation and natural killer function. In the present work, at physiological (15ng/ml) and stress-induced levels (30ng/ml) of p...

Plasma prolactin level and plasma renin activity were determined in normal subjects and patients with low and normal renin essential hypertension, renal hypertension, renovascular hypertension, primary aldosteronism, Cushing syndrome, pheochromocytoma and malignant hypertension. In both normal subjects and the normal renin essential hypertensives, plasma prolactin was significantly higher in fe...

INTRODUCTION Prolactin has been discussed as a factor likely to play a mediating role in multiple sclerosis (MS). Our aim was to investigate the possible association between prolactin production and clinical features of autoimmune demyelinating central nervous system disorders. METHODS Serum prolactin levels of 255 MS patients, 19 neuromyelitis optica (NMO) patients, 15 clinically isolated sy...

Genetic predisposition and exposure to alcohol and stress increase the risk for alcoholism, possibly by forming a threefold interaction. This is suggested by various aspects of alcohol-induced stress response dampening in offspring of alcoholics. We tested whether such an interaction is also revealed by prolactin secretion, which is predominantly controlled by hypothalamic dopamine. Plasma prol...

All atypical antipsychotics avoid extrapyramidal side-effects yet differ in their propensity to cause other side-effects, like prolactin elevation. We proposed that the atypical antipsychotics with a propensity for prolactin elevation would show a higher pituitary versus striatal D2 receptor occupancy. To investigate this hypothesis, we tested four atypical antipsychotics, two that are commonly...

OBJECTIVE To explore equation, if any, between findings of magnetic resonance imaging of pituitary gland and serum prolactin level. METHODS The retrospective, descriptive study was conducted at the Department of Radiology, Aga Khan University Hospital, Karachi, and related to patients' records from April 19, 2006 to April 23, 2009. Seventy patients underwent magnetic resonance imaging of brai...

Abbreviations: ICW – In-Cell Western assay, MAP2 – microtubule-associated protein 2, PBS – phosphate-buffered saline, RT – room temperature. Abstract. Although many studies have demonstrated the role of prolactin in the central nervous system, there is a considerable lack of known effects of prolactin on the parameters of neurogenesis and neuronal differentiation. The aim of the present study w...

BACKGROUND Prolactin is a peptide hormone necessary for normal breast development that may contribute to breast tumorigenesis. Estrogen is a significant positive regulator of prolactin synthesis; therefore, raloxifene, a selective estrogen receptor modulator under study as a breast cancer prevention agent, may modulate both estradiol and prolactin levels by inhibiting estradiol from binding to ...

This study was conducted to investigate the effect of women breast cancer on some hormones (Estrogen, Testosterone, prolactin) and biochemical parameters (Glucose, Cholesterol, Aromatase). The is done in Medical City Teaching Hospital Baghdad show age, body weight type feeding for with compared healthy women. Their age ranged between (24-70) years both groups. results showing high significant e...