transannular patch was placed and stent flow was interrupted with a clip. A 1500-g neonate diagnosed with pulmonary atresia with ventricular septal defect, right aortic arch, ductus left and left superior vena cava, was administered prostaglandin to 2 months and underwent a right MBT shunt. Prostaglandin perfusion was restarted at 24 h as saturation was <65%. Echocardiography detected no flow i...

Gastroparesis refractory to prokinetic agents poses a major challenge to the physician and patient, alike. In the past 5 years, electrical methods to treat gastroparesis have emerged from animal and human experiments to a potentially valuable tool in clinical gastroenterology. One of these methods, known as gastric electrical stimulation (GES), is being increasingly used in specialized centres ...

Adsorbance of certain prokinetic drugs, regulating the motility of the digestive tract, on a cytoprotective drug--sucralfate was investigated. The evaluation of adsorbance capability was carried out by means of a statistical method in in vitro conditions, taking into account environmental pH, concentration of the investigated drugs as well as the form of sucralfate. Obtained results prove that ...

Ginger (Zingiber officinale) is a spice traditionally used to treat indigestion, nausea and vomiting. Ginger extracts accelerate gastric emptying and stimulate gastric antral contractions. These effects are mainly due to the presence of gingerols and shogaols and their activity on cholinergic M receptors and serotonergic 5-HT and 5-HT receptors. Various researches on this subject have led to co...

Gastro-oesophageal reflux disease is common, with up to 10% of the general population experiencing heartburn on a daily basis. It is a chronic condition and follow-up studies indicate the presence of symptoms at least 20 years after initial diagnosis. In addition to lifestyle modifications, management usually involves the use of an acid suppressant from the H2-receptor antagonist or proton pump...

Metoclopramide, a prokinetic drug, has been documented to produce antinociceptive response in animal models through opioid pathways. Morphine has been shown to act through ATP sensitive potassium channels (KATP) to produce antinociceptive response. However, such a possibility has not been examined for metoclopramide. The present study investigated this using pharmacological tools. Acetic acid i...

The application of novel techniques to quantify gastric motor function and gastric emptying has yielded important insights into the prevalence, pathogenesis and clinical sequelae of gastroparesis. Both acute and chronic gastroparesis occur frequently; gastric emptying of solids is delayed in 30% to 50% of patients with diabetes mellitus, functional dyspepsia and gastroesophageal reflux disease....

To evaluate pre and post treatment results based on Laryngeal mucosal changes as assessed by direct videolaryngoscopy/stroboscopy using Belafsky scores. In our study we have evaluated laryngeal in patientswith dysphonia RSI 10 before after 6 months of with Tab. Pantoprazole Tab.Mosapride. This prospective was carried out 50 patients attending the ENT patient department ofa tertiary care referra...

Chronic cough is one of the most common symptoms in clinical practice that associated numerous negative consequences. The pathophysiology chronic complex, and its causes include respiratory diseases, neurological disorders, exposure to tobacco smoke, medications. Understanding physiology mechanisms hypersensitivity can improve outcome treatment. At turn 2019 2020, European Respiratory Society (...

Background Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility. Methods We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin. Results Both ITRs and g...