The nonsense-mediated mRNA decay pathway functions to degrade aberrant mRNAs that contain premature translation termination codons. In Saccharomyces cerevisiae, the Upf1, Upf2, and Upf3 proteins have been identified as trans-acting factors involved in this pathway. Recent results have demonstrated that the Upf proteins may also be involved in maintaining the fidelity of several aspects of the t...

AIMS Determine health effects of programmed physical activities on blood fats in peripheral arterial disease of lower limbs or in examinees on medication therapy and examinees performing programmed physical activities along with the medication therapy. METHODS Overall research has been carried out at the Clinic for Vascular Disease CCUS. Before involvement into the study, examinees had to mee...

Programmed cell death is an integral component of Caenorhabditis elegans development. Genetic and reverse genetic studies in C. elegans have led to the identification of many genes and conserved cell death pathways that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells. Molecular, cell bio...

High mobility group box 1 (HMGB1) acts a signaling molecule regulating a wide range of inflammatory responses in extracellular space. HMGB1 also stabilizes nucleosomal structure and facilitates gene transcription. Under pathophysiological conditions, nuclear HMGB1 is immediately transported to the cytoplasm through chromosome region maintenance 1 (CRM1). Recently, we have reported that up-regul...

This paper addresses the design, simulation and experimental validation of a Permanent-Magnet Synchronous Motor speed control. The control is based on the passivity strategy; special attention is paid on the stability control issue. SIMNON simulations illustrating the torque and speed response of the motor control are carried out to validate the control strategy. The algorithm control was progr...

The modulating voltages applied to the DIII-D gyrotrons are controlled by reference signals which are synthesized by arbitrary waveform generators. These generators allow ECH operators to pre-program reference waveforms consisting of ramps, flat tops, and various modulation shapes. This capability is independent of the DIII-D central timing and waveform facilities, which provides the ECH operat...