The laboratory medicine is advancing towards the use of molecular techniques and molecular diagnostics for the detection of leukemia, genetic disorders, preimplantation screenings, pharmacogenomics, infectious diseases, and cancers. Molecular diagnostics dates back to 1980s but now has grown exponentially. The field has a wide range of applications including identifying individuals at risk of d...

I discuss diagnostic methods for discriminant analysis. The equivalence with linear regression is noted and regression diagnostics are considered. The leverage is a function of the linear discriminant function and the Mahalanobis distance of the observation from the group mean. The distribution of this distance is approximately chi-square with degrees of freedom equal to the number of variables...

Methods for detecting influential observations for the Weibull model fit to censored data are discussed. These methods include: one-step deletion diagnostics, influence functions and curvature diagnostics. Results indicate that the curvature diagnostics may be helpful in detecting masking.

ric cancers. Methods: Current oncology PIPs were manually extracted from the EMA website for the study period 2007-2014. Primary variables included: indication, applicant, decision, decision date, and date of expected completion. Indications for approved PIPs were classified into five categories: brain tumors, diagnostics, leukemias/lymphomas, side effects, and solid tumors. Results: A total of...

Optimizing programs by applying source-to-source transformations is a prevalent practice among programmers. Particularly so, while programming for highperformance and cost-effective embedded systems, where the initial program is subject to a series of transformations to optimize computation and communication. In the context of parallelization and custom memory design, such transformations are a...

This article describes the software and underlined decision support models for the immunophenotype diagnostics of leukosis (leukemia) and lymphomas adjusted for the marker or human leukocyte antigen (CD-antigen) coexpressions. Using the model knowledge base, the decision inference algorithm allows computing the degree of manifestation of the disease subtypes for the input immunophenotype featur...

Yoon (2008, 2009) claimed that there are two distinct Subjects in Multiple Subject Constructions (MSCs) in Korean. The crux of his argument hangs on reinterpreting the traditionally proposed subject diagnostics as distinguishing between the Grammatical Subject (GS) and the Major Subject (MS) in MSCs. The claimed diagnostics for GS and MS were examined experimentally in MSCs and corresponding Si...

People can usually sense troubles in a car from noises, vibrations, or smells. An experienced driver can even tell where the problem is. We call this kind of skill ‘Ambient Diagnostics’. Ambient Diagnostics is an emerging field that is aimed at detecting abnormities from seemly disconnected ambient data that we take for granted. For example, the human body is a rich ambient data source: tempera...

Statistical diagnostic and correction of a chemistry-transport model for the prediction of total column ozone S. Guillas, G. C. Tiao, D. J. Wuebbles, and A. Zubrow School of Mathematics, Georgia Institute of Technology, Atlanta, Georgia, USA Graduate School of Business, University of Chicago, Chicago, Illinois, USA Department of Atmospheric Sciences, University of Illinois, Urbana, Illinois, US...

Aim. To determine the threshold value of Epstein-Barr virus (EBV) viral load (VL) in blood leukocytes to improve laboratory diagnostics infectious mononucleosis children. Materials and methods. EBV DNA quantification children aged 1-17 years (n=163) was determined by real-time polymerase chain reaction. VL were compared groups (n=67), non-EBV (n=25) healthy donors (n=25). Threshold based on dat...