Introduction: Human exfoliated deciduous teeth–derived stem cells (SHEDs) have been shown as an excellent source of bone regeneration. Interleukin-17A (IL-17A) facilitates differentiation in various cell types, including SHEDs. In this study, we demonstrated IL-17A’s stimulating effect on SHEDs osteogenic and further evaluated the role ERK/MAPK signaling pathway process. Methods: The function I...

Celiac disease (CD) is a gluten-sensitive enteropathy associated with a marked infiltration of the mucosa with IFN-gamma-secreting Th1 cells. Recent studies have shown that a novel subset of T cells characterized by expression of high levels of IL-17A, termed Th17 cells, may be responsible for pathogenic effects previously attributed to Th1 cells. In this study, we characterized the expression ...

Background: The objective of this study is to evaluate the progesterone level (P Level) on the day of HCG triggering in GnRh agonist and antagonist protocols, and its correlation with clinical pregnancy rate and miscarriage rate. Premature luteinization during in vitro fertilization (IVF) was commonly happened before the introduction of GnRh analogues. High level of unwanted progesterone that i...

In previous studies, the neuroprotective effect of progestrone in diffuse traumatic brain injury has been shown. This study used mifepristone (RU-486), a potent progesterone receptor antagonist, to evaluatethe hypothesis that the neuroprotective effect of progesterone in traumatic brain injury is mediated by the progesterone receptors. The ovariectomized rats were divided into 6 groups. Brain i...

background: premature luteinization during in vitro fertilization was commonly happened before the introduction of gnrh analogues. high level of unwanted progesterone is associated with adverse pregnancy outcome and is thought to be induced by inappropriate lh elevation.objective: to evaluate the progesterone level on the day of human chorionic gonadotropin (hcg) triggering in gnrh agonist and ...

background: in this study, we determined the serum levels of il-17a and il-10 in context with 1, 2 dihydroxy vitamin d3, parathormone and ca2+/pi ions to investigate their pathological or protective roles respectively in bone metabolism. methods: the bone mineral density (bmd) was determined for 1203 participants using energy x-ray absorptiometry. subjects with a history of diseases and using b...

The aim of this study was to evaluate changes that occur in motility parameters of progesterone treated mouse spermatozoa during course of hyperactivation. Mouse spermatozoa treated with different doses of progesterone were videotaped after 10 min and 90 min of incubation. For each sperm, one second of movement of the head-midpiece junction was traced from the videotape and for each tracing sev...

INTRODUCTION Accumulating evidence suggests an important role for interleukin 17 (IL-17) in the pathogenesis of several inflammatory diseases, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Accordingly, clinical trials aimed at blocking IL-17 have been initiated, but clinical results between patients and across different diseases have been highly variable. The objective was ...

Interleukin 17A (IL-17A) has been associated with protective rather than pathogenic response in Chagas disease (ChD). However, it is not established whether or not IL-17A-mediated immune response is correlated with patient's left ventricular (LV) function in ChD. To address this question we have gathered cardiac functional parameters from ChD patients and analysed the possible relationship betw...

background and objectives: endometrial hyperplasia (eh) is an abnormal overgrowth of endometrium that may lead to endometrial cancer, especially when accompanied by atypia. the treatment of eh is challenging, and previous studies report conflicting results. metformin (dimethyl biguanide) is an anti-diabetic and insulin sensitizer agent, which is supposed to have antiproliferative and anticancer...