The problem is trivially positive in R2. However, a surprising negative answer for n ≥ 12 was given by Larman and Rogers [LR] in 1975. Subsequently, a series of contributions were made to reduce the dimensions to n ≥ 5 by a number of authors (see [Ba], [Bo], [G2], [Gi], [Pa], and [Z1]). That is, the problem has a negative answer for n ≥ 5. See [G3] for a detailed description. It was proved by G...

This paper highlights one element that appears to be a major cause of corruption: inadequate public regulation. Based on a simple model of the interplay between the costs of acting in accordance with government regulations for individuals or their organizations, on one side, and the capacities of those individuals or organizations to comply with the regulations, on the other side, a series of r...

DNA interstrand cross-links are induced by many carcinogens and anticancer drugs. It was previously shown that mammalian DNA excision repair nuclease makes dual incisions 5' to the cross-linked base of a psoralen cross-link, generating a gap of 22 to 28 nucleotides adjacent to the cross-link. We wished to find the fates of the gap and the cross-link in this complex structure under conditions co...

Three mammalian nuclear lamin proteins, lamin B(1), lamin B(2) and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise r...

In 1994 in the Journal of Cell Science, Hennekes and Nigg reported that changing valine to arginine at the endoproteolytic cleavage site in chicken prelamin A abolishes its conversion to lamin A. The consequences of this mutation in an organism have remained unknown. We now report that the corresponding mutation in a human subject leads to accumulation of prelamin A and causes a progeroid disor...

In our institute, we have recently found a child Japanese monkey who is characterized by deep wrinkles of the skin and cataract of bilateral eyes. Numbers of analyses were performed to identify symptoms representing different aspects of aging. In this monkey, the cell cycle of fibroblasts at early passage was significantly extended as compared to a normal control. Moreover, both the appearance ...