نتایج جستجو برای: probucol

تعداد نتایج: 552  

Journal: :Revista latinoamericana de microbiologia 2002
M P Crisóstomo-Vázquez M P Cervantes-Cervantes E Jiménez-Cardoso J L Muñoz-Sánchez

Entamoeba histolytica is a parasite which causes health problems and there has been many approaches to know what is the factor causing its pathogenicity. In the present work, we assayed if the production of free radicals by the amoeba, has a relationship with the proteases activity. When we test the DMSO action (free radicals quenching activity) the specific activity of the proteases complex of...

Journal: :Journal of lipid research 1989
D W Morel G M Chisolm

Increased lipid peroxidation products were detected in a lipoprotein fraction containing very low density lipoprotein (VLDL) and low density lipoprotein (LDL) obtained from rats made diabetic by streptozotocin injection. The enhanced oxidation in the diabetic VLDL plus LDL fraction correlated with the in vitro toxicity of this lipoprotein fraction to proliferating fibroblasts. In contrast, high...

Journal: :Hypertension 2007
Pasquale Strazzullo Sally M Kerry Antonio Barbato Marco Versiero Lanfranco D'Elia Francesco P Cappuccio

A meta-analysis was performed of the effect of 3hydroxy3methylglutaryl-coenzyme A reductase inhibitors (statins) on blood pressure in humans including the randomized, controlled trials of statin therapy (20 trials and 828 patients) in which concomitant antihypertensive treatment (if any) remained unchanged throughout the study. A total of 291 and 272 patients were given a statin or placebo, res...

Journal: :Hypertension 2000
H N Hodis S Hashimoto W J Mack A Sevanian

The role of lipid peroxidation during the pathogenesis of atherosclerosis has been described through numerous studies and has provided compelling evidence for free radical-mediated processes that link hypertension with atherosclerosis. However, there remains only limited information concerning peroxidative processes in hypertension and their modulation by antioxidants. In the present study, the...

Journal: :The Journal of clinical investigation 1990
R Kaplan H S Aynedjian D Schlondorff N Bank

Recent studies indicate that short-term cholesterol feeding causes vascular hyperreactivity and/or increased tone in certain vascular beds. The present study in rats examined the effect of 3 wk of cholesterol-supplemented diet (CSD) on renal hemodynamics. We tested the hypothesis that LDL oxidized in vivo is causally related to increased renal vascular tone by adding the antioxidant drug probuc...

Journal: :Hypertension 2002
Norio Komai Ryuichi Morishita Shingo Yamada Mitsuru Oishi Sota Iguchi Motokuni Aoki Minako Sasaki Ikunosuke Sakurabayashi Jitsuo Higaki Toshio Ogihara

Although oxidized lipoproteins may play an important role in the progression of atherosclerosis, no report has mentioned the significance of oxidized lipoprotein (a) (Lp[a]) in the pathogenesis of cardiovascular disease. Initially, we compared the mitogenic actions of Lp(a) and oxidized Lp(a) on human vascular smooth muscle cells (VSMC). Lp(a) significantly stimulated the growth of human VSMC i...

Journal: :European journal of nutrition 2010
Weng-Cheng Chang Chia-Hsin Chen Ming-Fen Lee Ted Chang Ya-Mei Yu

BACKGROUND Expression of cell adhesion molecules (CAM) on the endothelium and the attachment of monocytes to endothelium may play a major role in the early atherogenic process. Chlorogenic acid is a phenolic compound present in coffee, apples, pears, berries, almonds, artichokes, and aubergines. Previous studies have indicated that CA possesses antioxidant activity in vitro. AIM We investigat...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Hong Yu Wenwu Zhang Patricia G Yancey Mark J Koury Youmin Zhang Sergio Fazio MacRae F Linton

OBJECTIVE Mice null for both apolipoprotein (apo)E and scavenger receptor (SR)-BI (DKO) develop severe hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarction, and premature death. The current study examines the ability of macrophage apoE to improve the dyslipidemia, reduce atherosclerosis, and rescue the lethal phenotype of DKO mice. METHODS AND RESULTS Initially, bon...

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