نتایج جستجو برای: probe drug
تعداد نتایج: 678746 فیلتر نتایج به سال:
یکی از ویژگی های اساسی مواد هادی مقاومت الکتریکی آن هاست که با داشتن تعداد الکترونهای آزاد لایه ظرفیت می توان مقاومت الکتریکی آن ماده را پیدا نمود. با اندازه گیری مقاومت الکتریکی مواد می توان ویژگیها و مشخصات ماده را تعیین نمود. در این پایان نامه بنا داریم به اندازه گیری مقاومت الکتریکی با استفاده چهار پراب همراستا با فاصله ثابت از هم که در تماس با سطح یک ویفر سیلیکونی هستند اقدام کنیم. در عم...
Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall plant cells or oocytes with springy cell membranes. When a reasonable design is created, ultrasou...
The present study aimed to investigate the effect of anlotinib (AL3818) on pharmacokinetics of cytochrome P450 (CYP) enzymes (CYP1A2, CYP2C6, CYP2D1, CYP2D2, and CYP3A1/2) by using five cocktail probe drugs in vivo. After pretreatment for 7 days with anlotinib (treatment group) or saline (control group) by oral administration, probe drugs phenacetin, tolbutamide, omeprazole, metoprolol, and mid...
Background: The prevalence of nontuberculous mycobacteria (NTM) infection has been increasing globally. Many cases NTM are misdiagnosed as Mycobacterium tuberculous (MTB) because similar clinicoradiological features. Objectives: To determine the burden and characteristics infection, this study was done to evaluate clinical isolates collected from (TB) suspects in a population Northwest China. M...
The accurate and high-throughput detection of drug resistance-related multiple point mutations remains a challenge. Although the combination of molecular beacons with bio-immobilization technology, such as microarray, is promising, its application is difficult due to the ineffective immobilization of molecular beacons on the chip surface. Here, we propose a novel asymmetric-loop molecular beaco...
Matrix metalloproteinases (MMPs) are zinc endopeptidases that play roles in numerous pathophysiological processes and therefore are promising drug targets. However, the large size of this family and a lack of highly selective compounds that can be used for imaging or inhibition of specific MMPs members has limited efforts to better define their biological function. Here we describe a protein en...
BACKGROUND Tuberculous meningitis (TBM) is the most severe form of extrapulmonary tuberculosis and causes high mortality and morbidity. Isoniazid resistance is strongly predictive of death in patients with TBM. METHODS In the present study, using polymerase chain reaction (PCR) and Genotype MTBDRplus line-probe assay, we investigated the drug resistance in patients with TBM living in Southwes...
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