2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. it is soluble in protic solvents. primary and secondary amines are n-methylated by various methods such as direct alkylation of amines with hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. consequently, they aren't...

We developed a deductive database system PACADE (Protein Coordinate Analyzer with Deductive Engine) for analyzing three dimensional and secondary structures of protein. This system has an inference system and a relational database which stores the primary, secondary and tertiary structures converted from Brookhaven's Protein Data Bank (PDB). Users of PACADE can represent biological knowledge on...

Background: Studies on efficacy of various vaccines that prevent or reduce the primary and recurrent HSV-1 infection have demonstrated the importance of cellular immunity for protection against the infection. We previously used DNA vaccination to induce cellular immunity against HSV-1 infection in mice. Objective: The aim of our study was to evaluate the effect of LIGHT, a member of TNF super f...

2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't...

The success of replantation surgery is not judged by survival of the replanted part, but by the functional outcome attained. Hence, primary repair of all injured structures is the preferred aim. At times, constraints induced by the ischemia time and nature of injury preclude primary repair. In such situations, secondary procedures are inevitable. Secondary procedures are also frequently require...

it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

an energy based damage index based on a new nonlinear finite element (fe) approach applicable to rc structures subjected to cyclic, earthquake or monotonic loading is proposed. the proposed method is based on the evaluation of nonlinear local degradation of materials and taking into account of the pseudo-plastic hinge produced in the critical sections of the structure. a computer program is dev...