Proline derivatives with a C(γ)-exo pucker typically display a high amide bond trans/cis (K(T/C)) ratio. This pucker enhances n→π* overlap of the amide oxygen and ester carbonyl carbon, which favors a trans amide bond. If there were no difference in n→π* interaction between the ring puckers, then the correlation between ring pucker and K(T/C) might be broken. To explore this possibility, prolin...

In this study, we examine the interaction between two bacterial proteins, namely HPr and IIAmtl of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system, using FTIR spectroscopy. In an interaction involving a 1:1 molar ratio of these two proteins, when they are unlabeled, the overlap of absorbance of the amide I band arising from the peptide group vibrations of the two pr...

BACKGROUND Glucagon-like peptide-1 (GLP-1)(7-36) amide is an intestinal incretin hormone which also inhibits gastric acid secretion in humans. Its mechanism of action is unclear, but it strongly inhibits vagally induced secretion (sham feeding), suggesting that it could influence vagal activity. AIM/METHODS The effect of intravenous GLP-1 (7-36 amide) (1 pmol/kg/min) was studied on pentagastr...

The title structures, [Zn2(C3H6NS2)4(C14H14N4O2)]·2C3H7NO (I) and [Zn2(C7H14NS2)4(C14H14N4O2)] (II), each feature a bidentate, bridging bipyridyl-type ligand encompassing a di-amide group. In (I), the binuclear compound is disposed about a centre of inversion, leading to an open conformation, while in (II), the complete mol-ecule is completed by the application of a twofold axis of symmetry so ...

We have directly determined the amide band resonance Raman spectra of the "average" pure alpha-helix, beta-sheet, and unordered secondary structures by exciting within the amide pi-->pi* transitions at 206.5 nm. The Raman spectra are dominated by the amide bands of the peptide backbone. We have empirically determined the average pure alpha-helix, beta-sheet, and unordered resonance Raman spectr...

in this paper we introduce the notion of classical quasi-primary submodules that generalizes the concept of classical primary submodules. then, we investigate decomposition and minimal decomposition into classical quasi-primary submodules. in particular, existence and uniqueness of classical quasi-primary decompositions in finitely generated modules over noetherian rings are proved. moreover, w...

The influence of arylthiols on cysteine-free ligation, i.e. the reaction between an alkyl thioester and a primary amine forming an amide bond, was studied in a polar aprotic solvent. We reacted the ethylthioester of hippuric acid with cyclohexylamine in the absence or presence of various quantities of thiophenol (PhSH) in a slurry of disodium hydrogen phosphate in dry DMF. Quantitative conversi...

Three families of anionic sugar-based surfactants bearing a sulfate functional group on the primary position monosaccharide were synthesized and their physicochemical properties compared. The first family corresponds to 6-sulfate derivatives commercially available octa- dodecyl β-d-gluco- galactopyranosides. second third contain an amide linker between sulfated (galactose, glucose or xylose) hy...

Efficient total syntheses of fluvibactin and vibriobactin have been achieved via molybdenum(VI) oxide-catalyzed dehydrative cyclization, Sb(OEt)(3)-catalyzed ester-amide transformation, and WSCI and HOAt-promoted dehydrative amide formation.

deviation from planarity—such as observed during cis/trans isomerization occurring in protein folding—should result in major changes in reactivity and other chemical properties of the amide bond. For example, rotation of the amide bond is coupled with formal rehybridization of the nitrogen atom to sp, with attendant pyramidalization and greatly increased basicity. The most common experimental a...