Flow simulation is a computational tool for exploring science and technology involving flow applications. It can provide cost-effective alternatives or complements to laboratory experiments, field tests and prototyping. Flow simulation relies heavily on high performance computing (HPC). We view HPC as having two major components. One is advanced algorithms capable of accurately simulating compl...

Hippocampal (HPC) theta oscillations have long been linked to various functions of the brain. Many cortical and subcortical areas that also exhibit theta oscillations have been linked to functional circuits with the hippocampus on the basis of coupled activities at theta frequencies. We examine, in freely moving rats, the characteristics of diencephalic theta local field potentials (LFPs) recor...

Intracranial hemangiopericytomas (HPCs) are rare tumors and their radiological appearance resembles that of meningiomas, especially meningothelial meningiomas. To increase the knowledge on the biochemical composition of this type of tumor for better diagnosis and prognosis, we performed a molecular study using ex vivo high resolution magic angle s...

Virtualization has become increasingly popular for enabling full system isolation, load balancing, and hardware multiplexing. This wide-spread use is the result of novel techniques such as paravirtualization that make virtualization systems practical and efficient. Paravirtualizing systems export an interface that is slightly different from the underlying hardware but that significantly streaml...

Accumulated studies have suggested that mitogen-activated protein kinase (MAPK) play a pivotal role in the development of cerebral hypoxic preconditioning (HPC). By using our "auto-hypoxia"-induced HPC mouse model, we have reported increased phosphorylation level of p38 MAPK, and decreased phosphorylation and protein expression levels of extracellular signal regulated kinases 1/2 (ERK1/2) in th...

This study aims to assess the effect of sodium chloride attack on mechanical and durability properties high-performance concrete (HPC) based fibers natural pozzolans. The resistance specimens against chemical is determined by unit weight, compressive strength, splitting-tensile ion permeability, apparent gas visual inspection after 28, 90, 180, 365 days testing. A total three types are assessed...

The host tissue microenvironment influences malignant cell proliferation and metastasis, but little is known about how tumor-induced changes in the microenvironment affect benign cellular ecosystems. Applying dynamic in vivo imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments th...

The contribution of specific cell types to the production of cytokines that regulate hematopoiesis is still not well defined. We have previously identified T cell-dependent regulation of hematopoietic progenitor cell (HPC) numbers and cycling. In this report, we demonstrated that HPC activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not because of decreased express...

Traditionally high-performance computing (HPC) systems have been optimized to support mostly monolithic workloads. The workload of many important scientific applications however, is comprised of spatially and temporally heterogeneous tasks that are often dynamically inter-related. These workloads can benefit from being executed at scale on HPC resources but a tension exists between their resour...

Key computational kernels must run near their peak efficiency for most high performance computing (HPC) applications. Getting this level of efficiency has always required extensive tuning of the kernel on a particular platform of interest. The success or failure of an optimization is usually measured by invoking a timer. Understanding how to build reliable and context-sensitive timers is one of...