A palladium-catalyzed oxidative coupling of arene C-H bonds with benzylic ethers via C-H bond activation is described. The reaction proceeds efficiently with a broad range of substrates bearing conventional directing groups with excellent functional group compatibility. This protocol potentially provides opportunities to use dibenzyl ethers as new acyl equivalents for catalytic acylation reacti...

substituted naphthofurans and naphthopyrans were constructed at high temperature from allyl or propargyl naphthyl ethers via claisen rearrangement in moderate to good yields. also, substituted (trimethylsilyl)-naphthofurans were synthesized from the corresponding naphtofurans.

Kathryn Rosica of the Chemical Manufacturers Association raised an interesting point in her letter (EHP vol. 102, p. 1006). Neither the term "glycol ethers" nor the term "ethylene glycol ethers" strictly identifies a class of chemicals whose members all share a common distinctive toxicological profile. As Rosica correctly noted, "Higher molecular weight ethylene glycol monoethers that have been...

Mukaiyama Michael addition of silyl enol ethers 13 to the 1,2-quinone-4-carboxylate 6 (formed in situ by oxidation of the catechol ester 8) afforded the 2-subsituted 7-hydroxybenzofuran-4-carboxylates 14 in fair to good yields. Alkyl and aryl systems work well, but highly electron-rich silyl enol ethers could not be used because of competing oxidation.

An efficient method for the synthesis of enol ethers and enecarbamates has been developed based on catalytic hydrosilane reduction of alpha-phosphonoxy enol ethers and alpha-phosphonoxy enecarbamates. This method has been applied to the total syntheses of two isoindolobenzazepine alkaloids, lennoxamine and chilenine.

silica chloride converted benzyl or tert-butyl esters to the corresponding acid chlorides and alkyl chlorides. it also converted benzyl or tert-butyl phenyl ethers to the corresponding allcyl chlorides and phenol

Exposure of 3-phenylpropyl ethers to an activated iodosylbenzene monomer·18-crown-6 complex [PhI(OH)BF(4)·18C6] in the presence of BF(3)-Et(2)O and water results in the para-selective monofluorination of benzene ring via neighboring alkoxy group participation and directly affords 3-(4-fluorophenyl)propyl ethers regioselectively in good yields.

Stereoselective synthesis of 5-7 membered cyclic ethers was achieved by deiodonative ring-enlargement of cyclic ethers having an iodoalkyl substituent. The reaction took place readily under mild conditions using hypervalent iodine compounds and an acetoxy or a trifluoroacetoxy group was introduced into the rings depending on the hypervalent iodine reagent employed. The use of hexafluoroisopropa...

An efficient and selective method was developed for the deprotection of triethylsilyl (TES) ethers using formic acid in methanol (5-10%) or in methylene chloride 2-5%) with excellent yields. TES ethers are selectively deprotected to the corresponding alcohols in high yields using formic acid in methanol under mild reaction conditions. Other hydroxyl protecting groups like t-butyldimethylsilyl (...