Dopamine receptors are involved in the expression of grooming behavior. The pregnancy-induced increase in self-licking observed in rats is important for mammary gland development and lactation. This study focuses on the role of dopamine receptor subtypes in grooming behavior of virgin and pregnant female rats. General and mammary gland grooming were measured in virgin rats treated with 0.25 mg/...

Two groups of female rats were used to investigate vitamin D metabolism in the pregnant animals and in their fetuses. In the first group, 3 wg of 25-hydroxyvitamin D3 (25-OH-D 3) per kg of body weight were injected into intact or nephrectomized (NX) pregnant rats 3 h before sacrifice on day 21 of pregnancy ; in the second group, 2 and 6 ng, respectively, of 1,25-dihydroxyvitamin D3 (1,2510H1 2)...

Hooded rats were operated to achieve maximum removal of cortical tissue (decorticationDC). DC was achieved which was later confirmed by serial histology. The rats and well matched controls were studied as to their reproductive cyclicity using vaginal smear technique, and their ability to achieve functional oestrus and mating – including pregnancy. From histological demonstrations, two groups of...

We previously observed that osmoregulation and the osmotic threshold for antidiuretic hormone secretion were altered during pregnancy in Sprague-Dawley rats and the present study evaluated the influence of volume on arginine vasopressin (AVP) release during gestation in this species. Basal plasma osmolality (Posm) and intravascular volume were 297 +/- 3 mosmol/kg and 16.2 +/- 1.2 ml in virgin a...

BACKGROUND Cancer-cachexia induces a variety of metabolic disorders of protein turnover and is more pronounced when associated with pregnancy. Tumour-bearing pregnant rats have impaired protein balance, which decreases protein synthesis and increases muscle breakdown. Because branched-chain amino acids, especially leucine, stimulate protein synthesis, we investigated the effect of a leucine-ric...

Objective: To study the teratogenic effects of Bisphenol A exposure during maternal pregnancy and lactation on testicular histology developing rat pups.
 Design Study: Laboratory-based experimental study.
 Place Duration Department Anatomy, Islamic International Medical College Rawalpindi in collaboration with National Institute Health (NIH) Islamabad Pakistan from Sep 2018 to 2019.&#...

Pregnancy worsens renal function in females with chronic renal failure (CRF) through an unknown mechanism. Reduced nitric oxide (NO) generation induces renal injury. Arginine transport by cationic amino acid transporter-1 (CAT-1), which governs endothelial NO generation, is reduced in both renal failure and pregnancy. We hypothesize that attenuated maternal glomerular arginine transport promote...

Preeclampsia, new onset hypertension with proteinuria during pregnancy, is associated with chronic inflammation and placental oxidative stress (ROS). Chronic interleukin-17 (IL-17) increases blood pressure, autoantibodies (angiotensin II type I receptor [AT1-AA]), and ROS during pregnancy. The objective of this study was to determine whether T-helper 17 (TH17) suppression via IL-17 recombinant ...

Cadorette, C., B. Sicotte, M. Brochu, and J. St-Louis. Effects of potassium channel modulators on myotropic responses of aortic rings of pregnant rats. Am. J. Physiol. Heart Circ. Physiol. 278: H567–H576, 2000.—The contribution of potassium channels [ATP-sensitive potassium (KATP) and high-conductance calcium-activated potassium (BKCa) channels] in the resistance of aortic rings of term pregnan...