PURPOSE The rapid increase in the incidence of precocious puberty in Korea has clinical and social significance. Gonadotropin-releasing hormone (GnRH) stimulation test is required to diagnose central precocious puberty (CPP), however this test is expensive and time-consuming. This study aimed to identify factors that can predict a positive response to the GnRH stimulation test. METHODS Clinic...

In the setting of central precocious puberty (CPP), the motivation for hormonal intervention is to help the child to reach a taller adult stature than she would achieve otherwise. While gonadotropin-releasing hormone analogs (GnRHa) constitute an established treatment for improving adult stature in girls presenting with CPP up to age 6 (true precocious puberty), it is not yet clear whether or n...

The addition of recombinant human growth hormone (rhGH) to GnRH agonist (GnRHa) to treat central precocious puberty (CPP) is controversial. We systemically reviewed and evaluated the efficacy and safety of the rhGH and GnRHa adjunctive therapy in Chinese children with CPP and assessed the influence of age and therapy duration on the efficacy of the combined treatment. A total of 464 patients we...

At puberty in girls the sex hormones are secreted in increasing quantities and the clinical signs of puberty follow. In precocious puberty it is generally accepted that the excretion of these hormones will reach adolescent or adult levels but will not be abnormally high as it may be in tumour or hyperplasia of the gonad or the adrenal cortex. Published reports vary depending on the laboratory i...

Introduction Accelerated development of secondary sexual characteristics or sexual precocity is a well-known entity [1–3]. Most authors recognize two groups of patients, those described as having central precocious puberty (CPP) and those with precocious pseudopuberty [1–3,6]. CPP results from premature activation of the hypothalamic-pituitary-gonadal axis and pseudopuberty is caused by lesions...

OBJECTIVE The incidence of idiopathic precocious puberty (IPP) might have an increasing trend. But the causes and risk factors of IPP are unknown. The objective of our study is to evaluate the effects of growth environments and two environmental endocrine disruptors (EDCs), zearalenone (ZEA), and 1,1-dichloro-2,2,bisethylene (p,p'-DDE), on patients with IPP. DESIGN Case-control study. METHO...