Benznidazole (BNZ) is traditionally used to treat Chagas disease. Despite its common use, BNZ has a poor water solubility and a variable bioavailability. The purpose of this study was to prepare BNZ microcrystals by solvent change precipitation and to study the effects of BNZ micronisation on therapeutic efficiency using a murine model of Chagas disease. The solvent change precipitation procedu...

OBJECTIVE To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. METHODS Five ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. RESULTS The dissolution...

A simple one-dimensional model for crystal dissolution and precipitation is presented. The model equations resemble a one-phase Stefan problem and involve nonlinear and multi-valued exchange rates at the free boundary. The original equations are formulated on a variable domain. By transforming the model to a fixed domain and applying a regularization, we prove the existence and uniqueness of a ...

A simple 1D model for crystal dissolution and precipitation is presented. The model equations resemble a one-phase Stefan problem and involve non-linear and multivalued exchange rates at the free boundary. The original equations are formulated on a variable domain. By transforming the model to a fixed domain and applying a regularization, we prove the existence and uniqueness of a solution. The...

Surveys using conservation detection dogs have grown increasingly popular as an efficient means to gather monitoring data, particularly for elusive and low-density species such as carnivores. Working with dogs can greatly increase the area surveyed for wildlife and the detection rate of survey targets. Due to the confounding effects of scent dispersion and dog movement, however, it can be diffi...

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melte...