Microglia are highly dynamic components of the innate immune system. In this issue of Neuron, Elmore et al. (2014) report that global depletion of microglia triggers mobilization of latent microglial progenitors throughout the CNS, resulting in rapid repopulation.

The sight of an object triggers a complex set of processes in the brain. Although it is already well established that object perception is performed by a hierarchical network, the so-called ventral visual pathway, we are only starting to understand how neurons along this pathway encode visual information at each processing stage. In this review, we discuss basic principles of neural coding for ...

Background On-site monitoring is a high-cost process, particularly if used indiscriminately in a large multicentre clinical trial. Ideally, the focus should be on identification and resolution of serious problems in trial conduct affecting patient safety and/or data quality. Targeted monitoring, where trial data and conduct are scrutinised centrally, with prespecified triggers for site visits, ...

Background. Dengue outbreaks are occurring with increasing frequency and intensity. Evidence-based epidemic preparedness and effective response are now a matter of urgency. Therefore, we have analysed national and municipal dengue outbreak response plans. Methods. Thirteen country plans from Asia, Latin America and Australia, and one international plan were obtained from the World Health Organi...

Human memory stores vast amounts of information. Yet recalling this information is often challenging when specific cues are lacking. Here we consider an associative model of retrieval where each recalled item triggers the recall of the next item based on the similarity between their long-term neuronal representations. The model predicts that different items stored in memory have different proba...

Post-synthetic derivatisation of a porous material produces a functionalized material that binds the metal complex V(O)acac2, in contrast to the unfunctionalized precursor, which is inactive for complex binding.