Mouse models are commonly used for studying hepatocellular carcinoma (HCC) biology and exploring new therapeutic interventions. Currently three main modalities of HCC mouse models have been extensively employed in pre-clinical studies including chemically induced, transgenic and transplantation models. Among them, transplantation models are preferred for evaluating in vivo drug efficacy in pre-...

Serotonin is reported to be present in early embryos of many species and plays an important role in early patterning. Since it is a fluorophore, it can be directly visualized using fluorescence microscopy. Here, we use three-photon microscopy to image serotonin in live pre-implantation mouse embryos. We find that it is present as puncta averaging 1.3 square microns and in concentrations as high...

Metastatic pancreatic adenocarcinoma (mPDAC) has a poor prognosis with 5-year survival rate of 3%. In non-metastatic, unresectable locally advanced cancer (LAPC) patients, endoscopic-ultrasound (EUS)-guided intra-tumoral phosphorus-32 ( 32 P)-microparticles implantation resulted in local disease control [LDCR] (defined as Stable Disease [SD] or better) at 16 weeks (3 months post-implantation) 9...

Implantation metastasis occurs when tumor seeds into a wound or tissue by a significant amount of viable tumor cells. Here we describe the case of a 30-year-old man suffering from pain and swelling of the foot, which was misdiagnosed as a bone cyst. Surgery was performed involving curettage followed by bone grafting. After surgical pathology, the exact diagnosis was revealed as the synovial sar...

BACKGROUND The aim of this study was to investigate the echocardiographic features of functional mitral regurgitation (MR) in patients with aortic stenosis (AS) pre- and post-trans catheter aortic valve implantation (TAVI). METHODS The study subjects consisted of 79 patients with severe AS, who underwent TAVI. The echocardiographic parameters related to MR severity prior to TAVI and the chang...

By acting through its receptors (RXFP1, RXFP2), relaxin (RLN) exerts species-specific effects during pregnancy; possible luteotropic effects through stimulation of prolactin (PRL) release have been suggested. In the domestic dog (Canis lupus familiaris) serum PRL increases in pregnant bitches shortly after RLN appears in the circulation, and a possible functional relationship between the RLN an...

Introduction: Women with poorly controlled insulin-dependent diabetes mellitus (IDDM) have a much higher incidence of early pregnancy complications, these include spontaneous miscarriages, early growth delay, and congenital malformations. Most of the investigations have been devoted to the early post implantation and organogenesis period of pregnancy. In this research we studied the hyperglycem...

Lee CKF Department of Obstetrics and Gynecology, Faculty of Medicine, The university of Hong Kong, China Email: [email protected]

The prevalence of degenerative valvular diseases such as aortic stenosis has continued to rise due to an increase in the aging population globally [1, 2]. Transcatheter aortic valve implantation (TAVI) has emerged to the forefront of severe aortic stenosis treatment, starting with high-risk surgical patients [1, 2]. The minimally invasive approach of TAVI, as established from the promising resu...