Darrow and his associates (1, 2) have recently obtained evidence that a correlation exists between the concentration of serum bicarbonate, muscle potassium, and intracellular sodium from a study on rats subjected to procedures designed to produce a deficit of one of the ions sodium, chloride, or potassium. Thus, the serum bicarbonate concentration was found to vary directly with the intracellul...

A method is described for the study of transport processes in ghosts isolated from rat adipose cells. With this procedure it was possible to follow the time course of potassium uptake, potassium release, and sodium release. The uptake of potassium was stimulated by sodium and was inhibited by ouabain at concentrations down to at least 10e6 M. In the presence of pyruvate (1 mu), potassium uptake...

The discovery of the renal outer medullary K+ channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K+ channel (K(ir)) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested...

OBJECTIVES The primary objective was to compare the efficacy of enteral potassium replacement (EPR) and intravenous potassium replacement (IVPR) as first-line therapy. Secondary objectives included comparison of adverse effects and number of doses required to resolve the episode of hypokalaemia. TRIAL DESIGN The EIPS trial is designed as a randomised, equivalence trial between two treatment a...

introduction: many of those who survive following an earthquake die in the next phase due to preventable and treatable medical conditions such as hyperkalemia. the present study aimed to evaluate the trend of potassium changes in crush syndrome patients of bam earthquake. methods: in this retrospective cross-sectional study, using the database of bam earthquake victims, which were developed by ...

Sixty patients with a first acute myocardial infarction and no current treatment with cardioactive drugs were included in a prospective study of the relationship between serum potassium concentration and the early occurrence of ventricular tachycardia and premature ventricular contractions (PVCs). Serum potassium level (range 2.5 to 5 mmol/liter) was estimated 3.8 +/- 2.5 hr (mean +/- SD) after...

The potassium channel TWIK-related acid sensitive potassium (TASK)-1 channel, together with other potassium channels, controls the low resting tone of pulmonary arteries. The Src family tyrosine kinase (SrcTK) may control potassium channel function in human pulmonary artery smooth muscle cells (hPASMCs) in response to changes in oxygen tension and the clinical use of a SrcTK inhibitor has resul...

The properties of potassium transport in carrot (Daucus carota L.) suspension culture cells and their isolated protoplasts were examined. Cells cultured in Murashige and Skoog (MS) medium (Plant Physiol 15: 473-497) were potassium saturated and, consequently, they exhibited little net potassium accumulation. Cells that transport and accumulate potassium were derived from the MS-grown cells by c...

IT has been shown in a previous paper (Cumings, 1939b) that the potassium content of muscle was abnormal in two diseases, except for conditions in which fat or fibrous tissue replacement of muscle occurs. Some further muscles from a variety of diseases have since been examined and the results have not given rise to any change of opinion. It has also been shown (Cumings, 1939b, 1940) that muscle...

OBJECTIVES/HYPOTHESIS Nasal irrigations are commonly employed to promote nasal hygiene in the treatment of various sinonasal conditions. Few studies have evaluated how the ionic composition of irrigation solutions affects olfactory performance. The purpose of this study was to determine the dose responsiveness of human olfactory thresholds for each of the following ions: potassium, sodium, and ...