Male Wistar rats were made potassium-deficient by feeding a diet low in potassium, while controls were pair-fed the same diet supplemented with potassium. Four weeks later 10 mg of T-1824 was injected into each rat. It was found that the characteristic granules which accumulate in the renal collecting tubule cells as a result of potassium deficiency were colored blue and that a diminished color...

The relation between the active potassium influx in the human red blood cell and the extracellular potassium concentration does not appear to be consistent with the Michaelis-Menten model, but is adequately described by a model in which two potassium ions are required simultaneously at some site or sites in the transport mechanism before transport occurs. The same type of relation appears to ex...

Functional regulation of potassium currents in developing neurons is pivotal for changes in excitability and action potential waveform. Here, we test whether an excess of potassium channel transcripts is sufficient to drive functional expression of potassium current and shortening of the duration of the action potential. Injection of Shaker-like potassium channel transcripts into two-cell stage...

In 1942 Winkler and Smith (1), studying the simultaneous renal clearances of exogenous creatinine and potassium in dogs following the injection of potassium salts, concluded that potassium is normally filtered at the glomerulus and subjected to a variable degree of tubular reabsorption. The highest potassium/creatinine clearance ratio obtained by these authors was 0.40. In 1948 Berliner and Ken...

Inherent smooth muscle tone and acetylcholine-induced contractions of the isolated longitudinal muscle from guinea pig ileum are inhibited by 1.2 M ethanol. The inhibitions are antagonized by high concentrations of calcium ion in the external medium. Previous work has indicated that an acetylcholine-induced increase in potassium efflux from the ileal muscle is also inhibited by ethanol and reac...

Inherent smooth muscle tone and acetylcholine-induced contractions of the isolated longitudinal muscle from guinea pig ileum are inhibited by 1.2 M ethanol. The inhibitions are antagonized by high concentrations of calcium ion in the external medium. Previous work has indicated that an acetylcholine-induced increase in potassium efflux from the ileal muscle is also inhibited by ethanol and reac...

The purpose of this study was to investigate the factors controlling membrane permeability to potassium of smooth muscle cells from rat aorta stimulated by depolarization. The increase 42K+ efflux (change in the rate constant) induced by depolarization (application of high concentrations of potassium chloride) was inhibited significantly by the calcium antagonists diltiazem and nisoldipine. Par...

BACKGROUND Hyperkalemia is one of the more serious complications of chronic kidney disease (CKD), and the cause of potassium retention is a reduction in urinary potassium excretion. However, few studies have examined the extent of the decrease of urinary potassium excretion in detail with respect to decreased renal function. METHODS Nine hundred eighty-nine patients with CKD (CKD stages G1 an...