PURPOSE To look for segregation of Visual System Homeobox 1 (VSX1) mutations in family members of a patient with keratoconus. METHODS Our initial molecular genetic studies conducted to identify the role of VSX1 in the causation of keratoconus had identified a novel mutation in one patient. He later presented to the clinic affected with vernal kerato conjunctivitis (VKC) accompanied by his bro...

PURPOSE To evaluate the sensitivity, specificity, and test accuracy of corneal biomechanical metrics and anterior segment data in differentiating keratoconus from healthy corneas. METHODS Comparative case series. Patients with and without keratoconus (gender and age-matched) were submitted for complete eye examinations including corneal hysteresis (CH) and corneal resistance factor (CRF) as m...

BACKGROUND Fleischer's ring is considered to be a characteristic of keratoconus, but we have seen a ring similar to Fleischer's ring in patients with secondary keratoconus, in which the cornea becomes thinner secondarily for undetermined reasons. CASES We report 6 cases of secondary keratoconus with a corneal epithelial ring similar to the Fleischer's ring pattern. OBSERVATIONS In these 6 c...

PURPOSE To describe the clinical outcome of corneal cross-linking (CXL) in a young child with keratoconus. METHODS This is a case report of a young girl with keratoconus with ophthalmologic findings and 3-year follow-up. Follow-up visits included visual acuity measurement, retinoscopy, corneal tomography, and topography. RESULTS A girl with Down syndrome was diagnosed with bilateral keratoc...

INTRODUCTION Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from improved understanding of mechanisms leading to this disease. We aim to investigate the replication of 11 single nucleotide polymorphisms (SNPs) with keratoconus. METHODS SNPs from loci previously found in association with ker...

Several surgical strategies have been proposed to improve visual function in patients with keratoconus who become contact lens intolerant1,2. In mild-tomoderate keratoconus, when the central cornea remains clear, intrastromal corneal ring segments (ICRS), and phakic intraocular lenses (PIOLs) may provide enough BSCVA, and sometimes uncorrected visual acuity (UCVA), to postpone and sometimes avo...

Purpose: Comparing the optical coherence tomography (OCT) pachymetry patterns in keratoconus suspect and normal people Methods: Thirty-two keratoconus suspects and 36 healthy eyes were selected within the age range of 20-30 yrs. Their pachymetry pattern was obtained through OCT Visante in the minimum thickness spot, upper and lower corneal difference (I-S), lower temporal, and upper nasal thick...

SUMMARY This paper describes two sibs in each of whom keratoconus posticus circumscriptus is associated with multiple abnormalities. These include short stature, mental retardation, cleft lip and palate, and vertebral anomalies. The authors have been unable to trace any former reports of an identical condition and suggest that the findings in these children may represent a previously unrecognis...

IMPORTANCE It is unknown whether a neurotrophic deficit or pathologic nerve morphology persists in keratoconus in the long term after corneal collagen cross-linking (CXL) treatment. Nerve pathology could impact long-term corneal status in patients with keratoconus. OBJECTIVE To determine whether CXL treatment of keratoconus results in normalization of subbasal nerve density and architecture u...