BACKGROUND AND OBJECTIVES Most studies in the literature correlating epidural opioids to postoperative shivering were carried out with obstetric patients whose thermoregulation center response might be different from non-pregnant patients. Our study aimed at comparing intra and postoperative shivering and other complications of epidural block with and without fentanyl in patients submitted to v...

BACKGROUND Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been investigated for anti-shivering effects in some trials. This current meta-analysis was conducted to evaluate the effectiveness of dexmedetomidine as a neuraxial adjuvant in preventing perioperative shivering. METHODS This systematic review and meta-analysis was registered in PROSPERO [www.crd.york.ac.uk/PROSPERO]...

BACKGROUND AND PURPOSE Hand warming and face warming, combined with inhalation of heated air, are reported to suppress shivering. However, hand or face temperature contributes only a few percent to control of shivering. Thus, it seems unlikely that manipulating hand or facial skin temperature alone would be sufficient to permit induction of therapeutic hypothermia. We tested the hypothesis that...

OBJECTIVE To determine the impact of counter warming (CW) with an air circulating blanket on shivering and metabolic profile during therapeutic temperature modulation (TTM). DESIGN A prospective observational study. SETTING An 18-bed neurologic intensive care unit. PATIENTS Fifty mechanically ventilated patients with brain injury undergoing TTM with automated surface and intravascular dev...

Three patients who had suffered episodes of spontaneous hypothermia are described. Circulatory control was normal for their age but there was evidence of a persistent defect of thermoregulatory mechanisms. In all patients vascular thermoregulatory reflexes dependent upon peripheral receptors were active and in two patients reflex shivering could be obtained. There appeared, however, to be a fai...

Dear Editor, Shivering happens frequently in 5 to 60% of surgical operations. 1 Though it occurs as a result of temperature reduction, it may occur in patients with a post-operative normal body temperature. 2 Shivering may be dangerous due to increasing effect of medicines, extension of recovery period, increased oxygen consumption or hemostatic dysfunction especially in patients with a low car...

The metabolism of halothane during and after anaesthesia was studied in eight patients of different age and body weight by estimating the concentration of halothane and one of its metabolites (bromide) in the blood. A gas chromatograph with an electron capture detector was used to estimate halothane, while blood bromide levels were measured by neutron activation analysis. There was an initial b...

Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeo...