We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV) contain regions in their 5' UTRs that stall and repress the enzymatic activity of the cellular 5'-3' exoribonuclease XRN1, resulting in dramatic changes in the stability of cellular mRNAs. We used biochemical assays, virus infections, and transfection of the HCV and BVDV 5' untranslated regions in the absenc...

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Numerical simulations of the natural and actuated unsteady flow over a three-dimensional low-aspect ratio wing are performed using Lattice Boltzmann method. The LBM simulations match the flow conditions and the detailed wing geometry from previous experiments, including the actuators that are installed internally along the leading edge of the wing. The present study focuses on the transient lif...

A convolutional autoencoder is trained using a database of airfoil aerodynamic simulations and assessed in terms overall accuracy interpretability. The goal to predict the stall investigate ability distinguish between linear non-linear response pressure distribution changes angle attack. After sensitivity analysis on learning infrastructure, we latent space identified by targeting extreme compr...

Translocation of a single stranded DNA (ssDNA) through an alpha -hemolysin channel in a lipid membrane driven by applied transmembrane voltage V was extensively studied recently. While the bare charge of the ssDNA piece inside the channel is approximately 12 (in units of electron charge) measurements of different effective charges resulted in values between one and two. We explain these challen...