The safety of long-acting beta-agonists (LABAs) has been hotly debated for several years, with surveillance studies suggesting increased risk of mortality, especially with use of LABA without inhaled corticosteroid (ICS). Meta-analyses of selected trials, especially those dominated by one large study, report significantly increased risks for mortality and Serious Adverse Events (SAEs). Review o...

This paper presents analyses of the 2006 and 2007 results of the Music Information Retrieval Evaluation eXchange (MIREX) Audio Cover Song Identification (ACS) tasks. The Music Information Retrieval Evaluation eXchange (MIREX) is a community-based endeavor to scientifically evaluate music information retrieval (MIR) algorithms and techniques. The ACS task was created to motivate MIR researchers ...

We propose a set of protocols for verifying quantum computing at any time after the computation itself has been performed. We provide two constructions: one requires five entangled provers and a completely classical verifier; the other requires a single prover, a verifier, who is restricted to measuring qubits in the X or Z basis, and one-way quantum communication from the prover to the verifie...

Dynamic causal modelling (DCM) was originally proposed as a hypothesis driven procedure in which a small number of neurobiologically motivated models are compared. Model comparison in this context usually proceeds by individually fitting each model to data and then approximating the corresponding model evidence with a free energy bound. However, a recent trend has emerged for comparing very lar...

OBJECTIVES The authors reviewed published clinical trial data on the effects of renin-angiotensin system (RAS) inhibition for the prevention of atrial fibrillation (AF), aiming to define when RAS inhibition is most effective. BACKGROUND Individual studies examining the effects of RAS inhibition on AF prevention have reported controversial results. METHODS All published randomized controlled...

the aim of the present study was to investigate and compare the effects of twokinds of motivational and instructional self–talk on the performance of static anddynamic balance tasks in the elderly. for this purpose, 45 old subjects agedbetween 60 and 70 from qom province participated in this study. static balancetask (stand on one leg) and dynamic balance task (sebt test) were instructed withno...

Subgroup analysis is designed to evaluate whether an intervention has differing effects according baseline characteristics of participants in clinical trials. This approach can help identify subgroups patient populations, within a single trial or across multiple trials (meta-analysis), that may benefit from the be hypothesis-generating for future Properly prespecified subgroup analyses increase...

Decision-making processes in everyday life are complex. Research on decision-making has focused self-report or experimental paradigms to understand this process. Recent work highlighted the potential for complex iterative frameworks. We developed a simulated paradigm assess relationship between in-game and real-world behaviors symptoms of depression through exploratory then pre-registered, conf...

The prerequisites under which ‘novel’ compounds have to show cardiovascular benefit on top of statin therapy have raised the bar for clinical endpoint studies. B-mode ultrasound measurement of the carotid intima media thickness (cIMT) is the best validated imaging modality and most widely used surrogate endpoint in intervention studies to evaluate treatment efficacy in the progression of athero...