Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that has an absolute requirement for iron which it transports from the host as heme and/or Fe(2 +). Iron transport must be regulated to prevent toxic effects from excess metal in the cell. P. gingivalis has one ferric uptake regulator (Fur) orthologue encoded in its genome called Har, which would be expected to regulate the transpo...

The interleukin (IL)-1β-processing inflammasome has recently been identified as a target for pathogenic evasion of the inflammatory response by a number of bacteria and viruses. We postulated that the periodontal pathogen, Porphyromonas gingivalis may suppress the inflammasome as a mechanism for its low immunogenicity and pathogenic synergy with other, more highly immunogenic periodontal bacter...

the bacterial population found in the gingival sulcus region in periodontitis consists of gram negative microorganisms; most of them are obligate anaerobes and capnophil, including porphyromonas, prevotella, fusobaclenuin, welinella, actinobacillus actinomycetem comitans, eiknella and capnocytohaga. this study has been carried out to investigate anaerobic and capnophilic bacteria from 206 speci...

Pendahuluan : Penyakit periodontal atau periodontitis adalah penyakit inflamasi yang disebabkan oleh bakteri pada jaringan pendukung (periodontal). Porphyromonas gingivalis anaerob gram negatif. Bakteri sering ditemukan dalam poket manusia, sekarang terlibat sebagai patogen utama untuk kronis. Penggunaan ekstrak herbal didalam kedokteran gigi berbagai keuntungan seperti agent plak antimikroba, ...

BACKGROUND Although previous studies have shown the presence of Porphyromonas endodontalis in chronic periodontitis associated with periapical lesions, the occurrence of this pathogen in diseased periodontal sites without periapical lesions has been poorly investigated. OBJECTIVE The aims of this study were to quantify P. endodontalis in patients with chronic periodontitis without periapical ...

systemic antibiotics and locally applied antimicrobial agents have been suggested to enhance clinical parameters. patients exhibiting aggressive periodontitis in particular benefit from adjunctive antibiotic therapy. the purpose of this investigation was to evaluate the effect of local antibiotic therapy with metronidazole adjunctively to scaling and root planning (srp) in the treatment of aggr...

Porphyromonas gingivalis is an oral human pathogen associated with the onset and progression of periodontitis, a chronic immune-inflammatory disease characterized by destruction teeth-supporting tissue. P. belongs to genus Porphyromonas, which being composed Gram-negative, asaccharolytic, non-spore-forming, non-motile, obligatory anaerobic species, inhabiting niches such as cavity, urogenital t...

BACKGROUND AND OBJECTIVES Gingival and periodontal diseases are associated with specific bacterial infections. The main aim of the study was to know whether the periodontitis is associated with an increased risk for acute myocardial infarction (AMI) and to know the distribution of Porphyromonas gingivalis in patients with acute myocardial infarction associated with chronic periodontitis and acu...

Propolis extract antimicrobial activity against periodontopathic (ATCC) bacteria was investigated “in vitro”. Bacterial strains tested were: Prevotella intermedia, Prevotella melaninogenica, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Capnocytophaga gingivalis and Fusobacterium nucleatum. Minimal inhibitory concentration (MIC) for the strains tested was determined using the ...

Porphyromonas gingivalis is implicated in chronic and aggressive periodontitis. This bacterium has numerous virulence factors and one is the Fimbriae, which is quite important for bacterial colonization. Fimbriae are appendices that anchor to the bacterial wall and are comprised of the protein FimBriline encoded by the FimA gene. Thus far, six genotypes have been identified, FimA I to V and Ib....