Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such experiments may involve indirect effects, these frequently remain uncharacterized. Here, analysis of functionally unrelated Saccharyomyces cerevisiae deletion strains reveals a common gene expression signature. One property shared by these...

The UK National Student Survey (NSS) represents a major resource, never previously used in the economics literature, for understanding how the market signal of quality in higher education works. In this study, we examine the determinants of the NSS overall student satisfaction score across eleven subject areas for 121 UK universities between 2007 and 2010. Using a unique panel data set and esti...

Linear mixed models are popular models for use with clustered and longitudinal data due to their ability to model variation at different levels of clustering. A Monte Carlo study was used to explore the impact of assumption violations on the bias of parameter estimates and the empirical type I error rates. Simulated conditions included in this study are: simulated serial correlation structure, ...

In process robustness studies, it is desirable to minimize the influence of noise factors on the system and simultaneously determine the levels of controllable factors optimizing the overall response or outcome. In the cases when a random effects model is applicable and a fixed effects model is assumed instead, an increase in the variance of the coefficient vector should be expected. In this pa...

Records on 65,536 Landrace pigs collected between 1985 and 1999 in herds on the National Swine Registry STAGES program were used to estimate additive genetic (animal), common environmental (litter), and residual variances and covariances for days to 250 lb, backfat, loin eye area, and lean growth rate. Analysis was by the REMLf90 program of I. Misztal using a multiple-trait animal model with fi...

pedigree information of 3972 holstein cows and bulls, from 1961 to 2008, was used to calculate inbreeding coefficients and their effects on production traits and subclinical mastitis of dairy farm cows inazerbaijan province,iran. inbreeding was included in a linear mixed model as a class variable. data were analyzed using the proc mixed of sas by mivque method. results showed that average inbre...

It is common knowledge that the genetic variability of plants, even of the same variety, can be very important and, if we add locally varying climatic effects, the development of two neighboring similar plants could be highly different. This is one of the reasons why population-based methods for modeling plant growth are of great interest. A highly promising individual-based plant growth model ...

The relationship between local government structure and expenditure has received considerable attention, yet there is little consensus on how the features of representative government affect local expenditure decisions. The sole exception is city council size, which has consistently been found to have a positive and significant impact on expenditure. Previous results rely on cross-sectional est...

The confirmation of the segregation of experimentally discovered quantitative trait loci (QTL) in a variety of commercial populations is required before their commercial significance can be fully realized. The use of complex pedigrees in the design of such confirmation experiments has the potential to increase the probability of the QTL segregating within the pedigree while maintaining the powe...

We discuss a method for combining different but related longitudinal studies to improve predictive precision. The motivation is to borrow strength across clinical studies in which the same measurements are collected at different frequencies. Key features of the data are heterogeneous populations and an unbalanced design across three studies of interest. The first two studies (CALGB 8881 and 916...