The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Tadalafil a BCS class II drug is an impotence agent. It is indicated for the treatment of erectile dysfunction and is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5).However, insolubility and poor dissolut...

At present about 40% of the drugs being in the development pipelines are poorly soluble, even up to 60% of compounds coming directly from synthesis are poorly soluble [1]. Poor solubility is in most cases associated with poor bioavailability. According to the Noyes-Whitney law the dissolution velocity dc/dt depends on the saturation solubility cs. There are two basic approaches to overcome the ...

We describe the first example of immunoanalysis performed within an ionic liquid with minimal deleterious effect; our results bode well for the development of second-generation biosensors, particularly in applications involving poorly water soluble analytes including pesticides, phospholipids, and illicit drugs.

Mechanism of the absorption of drugs from oil in water emulsions was studied in the rat large intestine. Synthesized esters of fatty acids and phthalic acid-0.1% Polysorbate 80 was chosen as the emulsion system, the oil/water volume ratio was varied from 0 to 1, and the absorption from emulsions of sulfapyridine, salicylamide, and of acetanilide was investigated using in situ recirculation and ...

Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipi...

Multidrug dosage forms (aka combination forms, polypills, etc.) create value for patients through reduced pill burdens and simplified administration to improve adherence therapy. Enhanced flexibility of multidrug would provide further opportunities better match emerging needs individualized Through modular form concepts, one approach satisfy these is adapt a wider variety drugs, each with doses...

Molecular transport mechanisms of poorly soluble hydrophobic drug compounds to lipid membranes were investigated using molecular dynamics (MD) simulations. The model compound danazol was used investigate the mechanism(s) by which bile micelles delivered it membrane. interactions between membrane and pure aggregates—in form amorphous aggregates nanocrystals—were also studied. Our simulations ind...

Abstract: Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve solubility slowly dissolving drugs. A variety pharmaceutically compatible additives using different emerging technology used for preparing SDs. Multiple approaches were designed prepare SDs by such as kneading, co-milling, fusion, solvent evaporation various solvent-associated methods. The selection a...