As the second abundant biomass in nature, chitin widely exists crustaceans, insects, plankton, fungi and so on. Thus, extracting from crustaceans’ seafood waste applying it its derivatives biomedicine represents idea of turning into treasure. However, poor solubility severely limits application range field chitin. chemical modification has always been a hot research such compounds, endowing bet...

The aim of this investigation was to improve the dissolution properties of the water-insoluble drug ezetimibe (EZE) and potentially improve bioavailability. A combination of melt and adsorption techniques was employed for the preparation of solid dispersions. PEG 4000, PEG 6000, and Gelucire 44/14 were used as hydrophilic carriers, and lactose monohydrate was used as an adsorbent. Phase solubil...

A novel supersaturated self-emulsifying drug delivery system (Super-SEDDS) loaded with scutellarin-phospholipid complex (SPC) was developed. The system aimed to address the limitations presented by conventional SEDDS as delivery carriers for drugs with poor water-solubility, low liposolubility and high dose. As an intermediate, SPC was first prepared based on the response surface design. The pr...

BACKGROUND The purpose of this study was to evaluate the effect of different pH solutions on the solubility and wear resistance of Silorane and dimethacrylate resin based composite restorative materials. MATERIALS AND METHODS Two different resin based restorative materials (Filtek Silorane P90 and hybrid composite Z100) were tested. Different pH solutions (2.5 and 5) also were used. A total o...

Extruded pellets were made based on deoiled rice bran and paddy husk using glycerol and cashew nut shell liquid as plasticizer. Effects of incorporation levels of glycerol (GL, 6 to 14 %) and cashew nut shell liquid (CNSL, 6 to 14%) on the physical and functional characteristics of extruded pellets based on deoiled rice bran and paddy husk powders were studied. For A3 samples (12% GL) radial ex...

• The Body's Need for Vitamins and Minerals in the Diet • Molecular Basis for Water Solubility and Fat Solubility (e.g., of Vitamins) Polarity of Solvent and Solute Thermodynamics of Dissolution • Structures and Functions of Key Vitamins • Effect of Olestra (Artificial Fat) on Vitamin Solubility • Quantitative Measures of Mineral Solubility Solubility Product (Ksp) Solubility (S) • Calcium in t...

The demand for a new solvent to treat oilsands was behind the purpose of this project; molecular dynamics simulation was used in this study. Supercritical water, supercritical carbon dioxide and other selected organic solvents in their supercritical state were studied. Meso-tetraphenyl porphyrin (H2TPP) and Octaethyl porphyrin (H2OEP) are the porphyrin model compounds and, 4’-Bis-(2-pyren-1-yl-...

1. The solubility of mustard (H) in water and in molar sodium chloride was found to be 5.8 x 10(-3) molar and 3.2 x 10(-3) molar respectively or 0.92 mg. per ml. and 0.5 mg. per ml. Solubility curves have been drawn and the usefulness of this method in examining the homogeneity of H preparations as well as in establishing their solubility, is discussed. 2. Certain detergents increase the solubi...

Satranidazole, a potent broad spectrum antiprotozoal, is a poorly water-soluble drug and has low bioavailability on oral administration. One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents. The solubility enhancement produced by binary blends with a cosolvent (dioxane) was studied against the solubility parameter of...